IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
Specificity
Natural and recombinant Rat Insulin-like growth factor-binding protein 4
"IGFBP3, 4, 5 and 6 expression at the mandibular condylar cartilage during rat growth and development." Hajjar D., Ricarte-Filho J.C.M., dos Santos M.F., Kimura E.T. Submitted (2004-07) to the EMBL/GenBank/DDBJ databases
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