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ELISA Kit for Rat High affinity nerve growth factor receptor

SKU : BHE13808223

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E9557r
Alternative Names	Neurotrophic tyrosine kinase receptor type 1 ; Slow nerve growth factor receptor ; p140-TrkA ; Trk-A ; Trk ; Trka
Categories	Elisa
Function	Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.
Specificity	Natural and recombinant Rat High affinity nerve growth factor receptor
Subcellular Location	Cell membrane Single-pass type I membrane protein Endocytosed to the endosomes upon treatment of cells with NGF.
Entryname	NTRK1_RAT
Method Type	Sandwich
Platform	PF07714
Protein Name	High affinity nerve growth factor receptor
Sequence	50: MLRGQRHGQL ; GWHRPAAGLG ; GLVTSLMLAC ; ACAASCRETC ; CPVGPSGLRC ; 100: TRAGTLNTLR ; GLRGAGNLTE ; LYVENQRDLQ ; RLEFEDLQGL ; GELRSLTIVK ; 150: SGLRFVAPDA ; FHFTPRLSHL ; NLSSNALESL ; SWKTVQGLSL ; QDLTLSGNPL ; 200: HCSCALLWLQ ; RWEQEDLCGV ; YTQKLQGSGS ; GDQFLPLGHN ; NSCGVPSVKI ; 250: QMPNDSVEVG ; DDVFLQCQVE ; GQALQQADWI ; LTELEGTATM ; KKSGDLPSLG ; 300: LTLVNVTSDL ; NKKNVTCWAE ; NDVGRAEVSV ; QVSVSFPASV ; HLGKAVEQHH ; 350: WCIPFSVDGQ ; PAPSLRWFFN ; GSVLNETSFI ; FTQFLESALT ; NETMRHGCLR ; 400: LNQPTHVNNG ; NYTLLAANPY ; GQAAASIMAA ; FMDNPFEFNP ; EDPIPVSFSP ; 450: VDTNSTSRDP ; VEKKDETPFG ; VSVAVGLAVS ; AALFLSALLL ; VLNKCGQRSK ; 500: FGINRPAVLA ; PEDGLAMSLH ; FMTLGGSSLS ; PTEGKGSGLQ ; GHIMENPQYF ; 550: SDTCVHHIKR ; QDIILKWELG ; EGAFGKVFLA ; ECYNLLNDQD ; KMLVAVKALK ; 600: ETSENARQDF ; HREAELLTML ; QHQHIVRFFG ; VCTEGGPLLM ; VFEYMRHGDL ; 650: NRFLRSHGPD ; AKLLAGGEDV ; APGPLGLGQL ; LAVASQVAAG ; MVYLASLHFV ; 700: HRDLATRNCL ; VGQGLVVKIG ; DFGMSRDIYS ; TDYYRVGGRT ; MLPIRWMPPE ; 750: SILYRKFSTE ; SDVWSFGVVL ; WEIFTYGKQP ; WYQLSNTEAI ; ECITQGRELE ; 799: RPRACPPDVY ; AIMRGCWQRE ; PQQRLSMKDV ; HARLQALAQA ; PPSYLDVLG
Sequence Length	799
String	P35739
Sub Unit	Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 which bridges NTRK1 to NGFR. Interacts with NGFR and KIDINS220. Can form a ternary complex with NGFR and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1.

Uniprot	P35739
Gene Name	Ntrk1
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:59109
Unigene	Rn.39098

Reference	1. "The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor." Meakin S.O., Suter U., Drinkwater C.C., Welcher A.A., Shooter E.M. Proc. Natl. Acad. Sci. U.S.A.89:2374-2378(1992) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM TRKA-II) 2. "Tissue-specific alternative splicing generates two isoforms of the trkA receptor." Barker P.A., Lomen-Hoerth C., Gensch E.M., Meakin S.O., Glass D.J., Shooter E.M. J. Biol. Chem.268:15150-15157(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORMS TRKA-I AND TRKA-II) 3. "Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses." Stephens R.M., Loeb D.M., Copeland T.D., Pawson T., Greene L.A., Kaplan D.R. Neuron12:691-705(1994) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SHC1 4. "Identification and characterization of novel substrates of Trk receptors in developing neurons." Qian X., Riccio A., Zhang Y., Ginty D.D. Neuron21:1017-1029(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PLCG1; SHC1; SH2B1 AND SH2B2;MUTAGENESIS OF VAL-527 5. "The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor." Wooten M.W., Seibenhener M.L., Mamidipudi V., Diaz-Meco M.T., Barker P.A., Moscat J. J. Biol. Chem.276:7709-7712(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SQSTM1 6. "An evolutionarily conserved transmembrane protein that is a novel downstream target of neurotrophin and ephrin receptors." Kong H., Boulter J., Weber J.L., Lai C., Chao M.V. J. Neurosci.21:176-185(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KIDINS220 7. "Association of the atypical protein kinase C-interacting protein p62/ZIP with nerve growth factor receptor TrkA regulates receptor trafficking and Erk5 signaling." Geetha T., Wooten M.W. J. Biol. Chem.278:4730-4739(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SQSTM1;SUBCELLULAR LOCATION;DOMAIN 8. "A unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane-spanning protein." Arevalo J.C., Yano H., Teng K.K., Chao M.V. EMBO J.23:2358-2368(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KIDINS220;DOMAIN 9. "Ternary complex with Trk, p75, and an ankyrin-rich membrane spanning protein." Chang M.-S., Arevalo J.C., Chao M.V. J. Neurosci. Res.78:186-192(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NGFR AND KIDINS220;DOMAIN 10. "SLAM-associated protein as a potential negative regulator in Trk signaling." Lo K.Y., Chin W.H., Ng Y.P., Cheng A.W., Cheung Z.H., Ip N.Y. J. Biol. Chem.280:41744-41752(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION;INTERACTION WITH SH2D1A 11. "The small GTPase Rab7 controls the endosomal trafficking and neuritogenic signaling of the nerve growth factor receptor TrkA." Saxena S., Bucci C., Weis J., Kruttgen A. J. Neurosci.25:10930-10940(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RAB7A 12. "Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth." Hisata S., Sakisaka T., Baba T., Yamada T., Aoki K., Matsuda M., Takai Y. J. Cell Biol.178:843-860(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH KIDINS220; MAGI2 AND RAPGEF2;INTERACTION WITH RAPGEF2;SUBCELLULAR LOCATION 13. "Neurotrophin receptor homolog-2 regulates nerve growth factor signaling." Wong A.W., Willingham M., Xiao J., Kilpatrick T.J., Murray S.S. J. Neurochem.106:1964-1976(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NRADD 14. "Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not." Nikoletopoulou V., Lickert H., Frade J.M., Rencurel C., Giallonardo P., Zhang L., Bibel M., Barde Y.A. Nature467:59-63(2010) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL DEATH

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