ELISA Kit for Rat Glutaredoxin-2, mitochondrial

Mfr.No.	E12991r
Alternative Names	Grx2
Categories	Elisa
Function	Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.
Specificity	Natural and recombinant Rat Glutaredoxin-2, mitochondrial
Subcellular Location	Isoform 2 Nucleus
Entryname	GLRX2_RAT
Platform	PF00462
Protein Name	Glutaredoxin-2, mitochondrial
Sequence	50: MSWYRAASVG ; RRLVASGRIL ; AGRRGAAGAA ; GSGMGNSTSS ; FWGKSATTPV ; 100: NQIQETISNN ; CVVIFSKSSC ; SYCSMAKKIF ; HDMNVNYKVV ; ELDMVEYGSQ ; 150: FQEALYKMTG ; ERTVPRIFVN ; GIFIGGAADT ; HRLHKEGKLL ; PLVHQCYLNK ; 157: SKRKDVE
Sequence Length	157
String	Q6AXW1
Sub Unit	Monomer; active form. Homodimer; inactive form. The homodimer is probably linked by 1 2Fe-2S cluster.

Have you used this product?

SKU	Supplier No.	Size	Your price	Quantity
BHE13804182	E12991r	96T	$796		Add to Cart