NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.
Specificity
Natural and recombinant Rat Glutamate receptor ionotropic, NMDA 1
Subcellular Location
Cell membrane Multi-pass membrane protein Cell junction synapse postsynaptic cell membrane Cell junction synapse postsynaptic cell membrane postsynaptic density Enriched in post-synaptic plasma membrane and post-synaptic densities.
Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked (By similarity). Found in a complex with GRIN2A or GRIN2B, GRIN3A and PPP2CB. Found in a complex with GRIN2A or GRIN2B and GRIN3B (By similarity). Interacts with DLG4 and MPDZ. Interacts with LRFN1 and LRFN2. Interacts with GCOM1.