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ELISA Kit for Rat Focal adhesion kinase 1

SKU : BHE13804371

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1178r
Alternative Names	Focal adhesion kinase-related nonkinase ; FRNK ; Protein-tyrosine kinase 2 ; p125FAK ; pp125FAK ; Fak ; Fak1
Categories	Elisa
Function	Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Microtubule-induced dephosphorylation at Tyr-397 is crucial for the induction of focal adhesion disassembly (By similarity). Plays a potential role in oncogenic transformations resulting in increased kinase activity.
Specificity	Natural and recombinant Rat Focal adhesion kinase 1
Subcellular Location	Cell junction focal adhesion Cell membrane Peripheral membrane protein Cytoplasmic side Constituent of focal adhesions.
Detection Range	78-5000pg/mL
Entryname	FAK1_RAT
Method Type	Sandwich
Platform	PF00373
Protein Name	Focal adhesion kinase 1
Sensitivity	40.4pg/mL
Sequence	50: MAAAYLDPNL ; NHTPSSSTKT ; HLGTGTERSP ; GAMERVLKVF ; HYFESSNEPT ; 100: TWASIIRHGD ; ATDVRGIIQK ; IVDSHKVKHV ; ACYGFRLSHL ; RSEEVHWLHV ; 150: DMGVSSVREK ; YELAHPPEEW ; KYELRIRYLP ; KGFLNQFTED ; KPTLNFFYQQ ; 200: VKSDYMLEIA ; DQVDQDIALK ; LGCLEIRRSY ; WEMRGNALEK ; KSNYEVLEKD ; 250: VGLKRFFPKS ; LLDSVKAKTL ; RKLIQQTFRQ ; FANLNREESI ; LKFFEILSPV ; 300: YRFDKECFKC ; ALGSSWIISV ; ELAIGPEEGI ; SYLTDKGCNP ; THLADFNQVQ ; 350: TIQYSNSEDK ; DRKGMLQLKI ; AGAPEPLTVT ; APSLTIAENM ; ADLIDGYCRL ; 400: VNGATQSFII ; RPQKEGERAL ; PSIPKLANNE ; KQGMRTHAVS ; VSETDDYAEI ; 450: IDEEDTYTMP ; STRDYEIQRE ; RIELGRCIGE ; GQFGDVHQGV ; YLSPENPALA ; 500: VAIKTCKNCT ; SDSVREKFLQ ; EALTMRQFDH ; PHIVKLIGVI ; TENPVWIIME ; 550: LCTLGELRSF ; LQVRKYSLDL ; ASLILYAYQL ; STALAYLESK ; RFVHRDIAAR ; 600: NVLVSSNDCV ; KLGDFGLSRY ; MEDSTYYKAS ; KGKLPIKWMA ; PESINFRRFT ; 650: SASDVWMFGV ; CMWEILMHGV ; KPFQGVKNND ; VIGRIENGER ; LPMPPNCPPT ; 700: LYSLMTKCWA ; YDPSRRPRFT ; ELKAQLSTIL ; EEEKVQQEER ; MRMESRRQAT ; 750: VSWDSGGSDE ; APPKPSRPGY ; PSPRSSEGFY ; PSPQHMVQTN ; HYQISGYPGS ; 800: HGIPAMAGSI ; YPGQASLLDQ ; TELWNHRPQE ; MSMWQPSVED ; SAALDLRGMG ; 850: QVLPPHLMEE ; RLIRQQQEME ; EDQRWLEKEE ; RFLKPDVRLS ; RGSIDREDGS ; 900: FQGPTGNQHI ; YQPVGKPDPA ; APPKKPPRPG ; APGHLSNLSS ; ISSPAESYNE ; 950: GVKPWRLQPQ ; EISPPPTANL ; DRSNDKVYEN ; VTGLVKAVIE ; MSSKIQPAPP ; 1000: EEYVPMVKEV ; GLALRTLLAT ; VDETIPILPA ; STHREIEMAQ ; KLLNSDLGEL ; 1050: ISKMKLAQQY ; VMTSLQQEYK ; KQMLTAAHAL ; AVDAKNLLDV ; IDQARLKMLG ; 1055: QTRPH
Sequence Length	1055
String	O35346
Sub Unit	Interacts with CAS family members. Interacts with GIT1. Interacts with SORBS1. Interacts with BCAR3. Interacts with SHB. Interacts with PXN. Component of a complex that contains at least FER, CTTN and PTK2/FAK. Interacts with BMX. Interacts with STEAP4. Interacts with ZFYVE21. Interacts with ESR1. Interacts with PIK3R1 or PIK3R2. Interacts with SRC. Interacts with EPHA2 (inactive form); participates to EPHA2 downstream signaling. Interacts with CD4; this interaction requires the presence of HIV-1 gp120. Interacts with EPHA1 (kinase activity-dependent) (By similarity). Interacts with RGNEF. Interacts with TGFB1I1.

Uniprot	O35346
Gene Name	Ptk2
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:25614
Unigene	Rn.2809

Reference	1. "Cloning of focal adhesion kinase, pp125FAK, from rat brain reveals multiple transcripts with different patterns of expression." Burgaya F., Girault J.A. Brain Res. Mol. Brain Res.37:63-73(1996) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) strain: Sprague-Dawley. tissue: Corpus striatum. 2. Sasaki T., Nagura K., Sasaki H. Submitted (1995-12) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 350-528 (ISOFORM 1) strain: Wistar. 3. "Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions." Matsuya M., Sasaki H., Aoto H., Mitaka T., Nagura K., Ohba T., Ishino M., Takahashi S., Suzuki R., Sasaki T. J. Biol. Chem.273:1003-1014(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TGFB1I1 4. "Subcellular redistribution of focal adhesion kinase and its related nonkinase in hypertrophic myocardium." Yi X.P., Wang X., Gerdes A.M., Li F. Hypertension41:1317-1323(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;PHOSPHORYLATION AT SER-722 AND SER-913;CHARACTERIZATION OF ISOFORM 2 5. "Direct interaction of focal adhesion kinase with p190RhoGEF." Zhai J., Lin H., Nie Z., Wu J., Canete-Soler R., Schlaepfer W.W., Schlaepfer D.D. J. Biol. Chem.278:24865-24873(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARHGEF28 6. "PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation." Kadare G., Toutant M., Formstecher E., Corvol J.C., Carnaud M., Boutterin M.C., Girault J.A. J. Biol. Chem.278:47434-47440(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-152;MUTAGENESIS OF LYS-152;INTERACTION WITH PIAS1;AUTOPHOSPHORYLATION;PHOSPHORYLATION AT TYR-397;SUBCELLULAR LOCATION 7. "Focal adhesion kinase in netrin-1 signaling." Ren X.R., Ming G.L., Xie Y., Hong Y., Sun D.M., Zhao Z.Q., Feng Z., Wang Q., Shim S., Chen Z.F., Song H.J., Mei L., Xiong W.C. Nat. Neurosci.7:1204-1212(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DCC 8. "Nuclear compartmentalization of FAK and FRNK in cardiac myocytes." Yi X.P., Zhou J., Huber L., Qu J., Wang X., Gerdes A.M., Li F. Am. J. Physiol.290:H2509-H2515(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;PHOSPHORYLATION;CHARACTERIZATION OF ISOFORM 2

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