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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Flap endonuclease 1

SKU : BHE13804205

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15243r
Alternative Names	Flap structure-specific endonuclease 1
Categories	Elisa
Function	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Specificity	Natural and recombinant Rat Flap endonuclease 1
Subcellular Location	Nucleus nucleolus Nucleus nucleoplasm Mitochondrion Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Entryname	FEN1_RAT
Platform	PF00867
Protein Name	Flap endonuclease 1
Sequence	50: MGIQGLAKLI ; ADVAPSAIRE ; NDIKSYFGRK ; VAIDASMSIY ; QFLIAVRQGG ; 100: DVLQNEEGET ; TSHLMGMFYR ; TIRMMENGIK ; PVYIFDGKPP ; QLKSGELAKR ; 150: SERRAEAEKQ ; LQQAQEAGAE ; EEVEKFTKRL ; VKVTKQHNDE ; CKHLLSLMGI ; 200: PYLDAPSEAE ; ASCAALAKAG ; KVYAAATEDM ; DCLTFGSPVL ; MRHLTASEAK ; 250: KLPIQEFHLS ; RVLQELGLNQ ; EQFVDLCILL ; GSDYCESVRG ; IGPKRAVDLI ; 300: QKHKSIEEIV ; RRLDPSKYPV ; PENWLHKEAR ; QLFLEPEVLD ; PESVELKWSE ; 350: PNEEELVKFM ; CGEKQFSEER ; IRSGVKRLNK ; SRQGSTQGRL ; DDFFKVTGSL ; 380: SSAKRKEPEP ; KGPAKKKAKT ; GGAGKFRRGK ;
Sequence Length	380
String	Q5XIP6
Sub Unit	Interacts with PCNA. Three molecules of Fen1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity. The C-terminal domain binds EP300. Can bind simultaneously to both PCNA and EP300. Interacts with DDX11.

Uniprot	Q5XIP6
Gene Name	Fen1
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:84490
Unigene	Rn.16664

Reference	1. "Cloning and characterization of a rat DNA structure-specific endonuclease (Fen-1)." Chen D., Cao G., Yang S., Li M., Chen J. Submitted (2000-06) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (2005-07) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] strain: Brown Norway. 3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Testis.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13804205	E15243r	96T	$796		Add to Cart

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