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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Fibroblast growth factor receptor 1

SKU : BHE13804060

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0074r
Alternative Names	Basic fibroblast growth factor receptor 1 ; MFR ; Proto-oncogene c-Fgr ; CD331 ; Flg
Categories	Elisa
Function	Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2A, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2A triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.
Specificity	Natural and recombinant Rat Fibroblast growth factor receptor 1
Subcellular Location	Cell membrane Single-pass type I membrane protein Nucleus Cytoplasm cytosol Cytoplasmic vesicle After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus.
Detection Range	0.156-10ng/mL
Entryname	FGFR1_RAT
Method Type	Sandwich
Platform	PF07679
Protein Name	Fibroblast growth factor receptor 1
Sensitivity	0.087ng/mL
Sequence	50: MWGWRGLLFW ; AVLVTATLCT ; ARPAPTLPEQ ; AQPWGVPVEV ; ESLLVHPGDL ; 100: LQLRCRLRDD ; VQSINWLRDG ; VQLAESNRTR ; ITGEEVEVRD ; SIPADSGLYA ; 150: CVTNSPSGSD ; TTYFSVNVSD ; ALPSSEDDDD ; DDDSSSEEKE ; TDNTKPNRRP ; 200: VAPYWTSPEK ; MEKKLHAVPA ; AKTVKFKCPS ; SGTPSPTLRW ; LKNGKEFKPD ; 250: HRIGGYKVRY ; ATWSIIMDSV ; VPSDKGNYTC ; IVENEYGSIN ; HTYQLDVVER ; 300: SPHRPILQAG ; LPANKTVALG ; SNVEFMCKVY ; SDPQPHIQWL ; KHIEVNGSKI ; 350: GPDNLPYDQI ; LKTAGVNTTD ; KEMEVLHLRN ; VSFEDAGEYT ; CLAGNSIGLS ; 400: HHSAWLTVLE ; ALEERPAVMT ; SPLYLEIIIY ; CTGAFLISCM ; VGSVIIYKMK ; 450: SGTKKSDFHS ; QMAVHKLAKS ; IPLRRQVTVS ; ADSSASMNSG ; VLLVRPSRLS ; 500: SSGTPMLAGV ; SEYELPEDPR ; WELPRDRLVL ; GKPLGEGCFG ; QVVLAEAIGL ; 550: DKDKPNRVTK ; VAVKMLKSDA ; TEKDLSDLIS ; EMEMMKMIGK ; HKNIINLLGA ; 600: CTQDGPLYVI ; VEYASKGNLR ; EYLQARRPPG ; LEYCYNPSHN ; PEEQLSSKDL ; 650: VSCAYQVARG ; MEYLASKKCI ; HRDLAARNVL ; VTEDNVMKIA ; DFGLARDIHH ; 700: IDYYKKTTNG ; RLPVKWMAPE ; ALFDRIYTHQ ; SDVWSFGVLL ; WEIFTLGGSP ; 750: NPGVPVEELF ; KLLKEGHRMD ; KPSNCTNELY ; MMMRDCWNAV ; PSQRPTFKQL ; 800: VEDLDRIVAL ; TSNQEYLDLS ; MPLDQDSPSF ; PDTRSSTCSS ; GEDSVFSHEP ; 822: FPEEPCLPRH ; PTQLANGGLN ; RR
Sequence Length	822
String	Q04589
Sub Unit	Monomer. Homodimer after ligand binding. Interacts predominantly with FGF1 and FGF2, but can also interact with FGF3, FGF4, FGF5, FGF6, FGF8, FGF10, FGF19, FGF21, FGF22 and FGF23 (in vitro). Ligand specificity is determined by tissue-specific expression of isoforms, and differences in the third Ig-like domain are crucial for ligand specificity. Affinity for fibroblast growth factors (FGFs) is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Likewise, KLB increases the affinity for FGF19, FGF21 and FGF23. Interacts (phosphorylated on Tyr-766) with PLCG1 (via SH2 domains). Interacts with FRS2A. Interacts (via C-terminus) with NEDD4 (via WW3 domain). Interacts with KL (By similarity). Interacts with SHB (via SH2 domain) and GRB10. Interacts with KAL1; this interaction does not interfere with FGF2-binding to FGFR1, but prevents binding of heparin-bound FGF2. Interacts with SOX2 and SOX3.

Uniprot	Q04589
Gene Name	Fgfr1
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:79114
Unigene	Rn.207203

Reference	1. "The structure and expression of the FGF receptor-1 mRNA isoforms in rat tissues." Yazaki N., Hiroko F., Mitsuhiro O., Toshisuke K., Nobuyuki I. Biochim. Biophys. Acta1172:37-42(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. "90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling." Hu Y., Fang X., Dunham S.M., Prada C., Stachowiak E.K., Stachowiak M.K. J. Biol. Chem.279:29325-29335(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RPS6KA1;SUBCELLULAR LOCATION 3. "The parathyroid is a target organ for FGF23 in rats." Ben-Dov I.Z., Galitzer H., Lavi-Moshayoff V., Goetz R., Kuro-o M., Mohammadi M., Sirkis R., Naveh-Many T., Silver J. J. Clin. Invest.117:4003-4008(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY

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SKU	Supplier No.	Size	Your price	Quantity
BHE13804060	E0074r	96T	$796		Add to Cart

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