ELISA Kit for Rat Fibroblast growth factor 23

Mfr.No.	E0746r
Categories	Elisa
Function	Regulator of phosphate homeostasis (By similarity). Inhibits renal tubular phosphate transport by reducing SLC34A1 levels (By similarity). Regulator of vitamin-D metabolism (By similarity). Negatively regulates osteoblasts differentiation and matrix mineralization (By similarity). Acts directly on the parathyroid to decrease PTH secretion. Upregulates EGR1 expression in the presence of KL.
Specificity	Natural and recombinant Rat Fibroblast growth factor 23
Subcellular Location	Secreted Secretion is dependent on O-glycosylation.
Detection Range	15.6-1000pg/mL
Entryname	FGF23_RAT
Method Type	Sandwich
Platform	PF00167
Protein Name	Fibroblast growth factor 23
Sensitivity	8.02pg/mL
Sequence	50: MLGACLRLLV ; GALCTVCSLG ; TARAYSDTSP ; LLGSNWGSLT ; HLYTATARNS ; 100: YHLQIHRDGH ; VDGTPHQTIY ; SALMITSEDA ; GSVVIIGAMT ; RRFLCMDLRG ; 150: NIFGSYHFSP ; ENCRFRQWTL ; ENGYDVYLSP ; KHHYLVSLGR ; SKRIFQPGTN ; 200: PPPFSQFLAR ; RNEVPLLHFY ; TARPRRHTRS ; AEDPPERDPL ; NVLKPRPRAT ; 250: PIPVSCSREL ; PSAEEGGPAA ; SDPLGVLRRG ; RGDARRGAGG ; TDRCRPFPRF ; 251: V
Sequence Length	251
String	Q8VI82
Sub Unit	Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL and heparan sulfate glycosaminoglycans that function as coreceptors.

Reference	1. "Rattus norvegicus fgf23." Itoh N. Submitted (2002-01) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. "Klotho converts canonical FGF receptor into a specific receptor for FGF23." Urakawa I., Yamazaki Y., Shimada T., Iijima K., Hasegawa H., Okawa K., Fujita T., Fukumoto S., Yamashita T. Nature444:770-774(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION 3. "The parathyroid is a target organ for FGF23 in rats." Ben-Dov I.Z., Galitzer H., Lavi-Moshayoff V., Goetz R., Kuro-o M., Mohammadi M., Sirkis R., Naveh-Many T., Silver J. J. Clin. Invest.117:4003-4008(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY

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