Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.
Specificity
Natural and recombinant Rat Ezrin
Subcellular Location
Apical cell membrane Peripheral membrane protein Cytoplasmic side Cell projection Cell projection microvillus membrane Peripheral membrane protein Cytoplasmic side Cell projection ruffle membrane Peripheral membrane protein Cytoplasmic side Cytoplasm cell cortex Cytoplasm cytoskeleton Localization to the apical membrane of parietal cells depends on the interaction with MPP5. Microvillar peripheral membrane protein (cytoplasmic side) (By similarity). Localizes to cell extensions and peripheral processes of astrocytes. Colocalizes with EZR and SLC9A3R2 at the apical cell membrane of glomerular epithelium cells.
Interacts with MCC, MPP5, PLEKHG6, SCYL3/PACE1, SLC9A3R1, SCYL3/PACE1 and TMEM8B. Interacts (when phosphorylated) with FES/FPS (By similarity). Found in a complex with EZR, PODXL and SLC9A3R2. Interacts with PODXL and SLC9A3R2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 427-586;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 28-35; 101-107; 263-273; 372-379; 428-435 AND 530-542;IDENTIFICATION BY MASS SPECTROMETRY
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PODXL AND SLC9A3R2;SUBCELLULAR LOCATION;TISSUE SPECIFICITY