ELISA Kit for Rat Eukaryotic translation initiation factor 5A-1

Mfr.No.	E2696r
Alternative Names	Eukaryotic initiation factor 5A isoform 1 ; eIF-5A ; eIF-4D
Categories	Elisa
Function	mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival (By similarity). May play an important role in brain development and function, and in skeletal muscle stem cell differentiation.
Specificity	Natural and recombinant Rat Eukaryotic translation initiation factor 5A-1
Subcellular Location	Cytoplasm Nucleus Endoplasmic reticulum membrane Peripheral membrane protein Cytoplasmic side Nucleus nuclear pore complex
Entryname	IF5A1_RAT
Platform	PF01287
Protein Name	Eukaryotic translation initiation factor 5A-1
Sequence	50: MADDLDFETG ; DAGASATFPM ; QCSALRKNGF ; VVLKGRPCKI ; VEMSTSKTGK ; 100: HGHAKVHLVG ; IDIFTGKKYE ; DICPSTHNMD ; VPNIKRNDFQ ; LIGIQDGYLS ; 150: LLQDSGEVRE ; DLRLPEGDLG ; KEIEQKYDCG ; EEILITVLSA ; MTEEAAVAIK ; 154: AMAK
Sequence Length	154
String	Q3T1J1
Sub Unit	Interacts with DHPS, with SDCBP and DOHH. Found in a complex with Ran and XPO4. The hypusine modification increases the interaction with XPO4.

Reference	1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Prostate. 2. Lubec G., Afjehi-Sadat L. Submitted (2006-11) to the UniProtKB [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 56-67 AND 87-109;IDENTIFICATION BY MASS SPECTROMETRY strain: Sprague-Dawley. tissue: Spinal cord. 3. "Insights on eukaryotic translation initiation factor 5A (eIF5A) in the brain and aging." Luchessi A.D., Cambiaghi T.D., Alves A.S., Parreiras-E-Silva L.T., Britto L.R.G., Costa-Neto C.M., Curi R. Brain Res.1228:6-13(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION 4. "Involvement of eukaryotic translation initiation factor 5A (eIF5A) in skeletal muscle stem cell differentiation." Luchessi A.D., Cambiaghi T.D., Hirabara S.M., Lambertucci R.H., Silveira L.R., Baptista I.L., Moriscot A.S., Costa-Neto C.M., Curi R. J. Cell. Physiol.218:480-489(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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