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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Ephrin type-A receptor 3

SKU : BHE13804179

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1114r
Alternative Names	EPH-like kinase 4 ; EK4 ; Tyrosine-protein kinase TYRO4 ; Rek4 ; Tyro4
Categories	Elisa
Function	Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.
Specificity	Natural and recombinant Rat Ephrin type-A receptor 3
Subcellular Location	Cell membrane Single-pass type I membrane protein
Detection Range	0.312-20ng/mL
Entryname	EPHA3_RAT
Method Type	Sandwich
Platform	PF14575
Protein Name	Ephrin type-A receptor 3
Sensitivity	0.161ng/mL
Sequence	50: MDCHLSILIL ; FGCCVLSCSR ; ELSPQPSNEV ; NLLDSKTIQG ; ELGWISYPSH ; 100: GWEEISGVDE ; HYTPIRTYQV ; CNVMDHSQNN ; WLRTNWVPRN ; SAQKIYVELK ; 150: FTLRDCNSIP ; LVLGTCKETF ; NLYYMESDDD ; HGVKFLEHQF ; TKIDTIAADE ; 200: SFTQMDLGDR ; ILKLNTEIRE ; VGPVNKKGFY ; LAFQDVGACV ; ALVSVRVYFK ; 250: KCPFTVKNLA ; MFPDTVPMDS ; QSLVEVRGSC ; VNNSKEEDPP ; RMYCSTEGEW ; 300: LVPIGKCTCN ; AGYEERGFIC ; QACRPGFYKA ; LDGVAKCTKC ; PPHSSTQEDG ; 350: SMNCRCENNY ; FRAEKDPPSM ; ACTRPPSAPR ; NVISNINETS ; VILDWSWPLD ; 400: TGGRKDITFN ; IICKKCGWNV ; RQCEPCSPNV ; RFLPRQLGLT ; NTTVTVTDLL ; 450: AHTNYTFEID ; AINGVSELSS ; PPRQFAAVSI ; TTNQAAPSPV ; MTIKKDRTSR ; 500: NSISLSWQEP ; EHPNGIILDY ; EVKYYEKQEQ ; ETSYTILRAR ; GTNVTISSLK ; 550: PDTTYVFQIR ; ARTAAGYGTN ; SRKFEFENSP ; DSFSISGENS ; HVVMIAISAA ; 600: VAIIVLTVVT ; YVLVGRFCGY ; HKSKHSSDEK ; RLHFGNGHLR ; LPGLRTYVDP ; 650: HTYEDPTQAV ; HEFAKELDAT ; NIAIDKVVGA ; GEFGEVCSGR ; LKLPSKKEIS ; 700: VAIKTLKVGY ; TEKQRRDFLG ; EASIMGQFDH ; PNIIRLEGVV ; TKSKPVMIVT ; 750: EYMENGSLDS ; FLRKHDAQFT ; VIQLVGMLRG ; IASGMKYLSD ; MGYVHRDLAA ; 800: RNILINSNLV ; CKVSDFGLSR ; VLEDDPEAAY ; TTRGGKIPVR ; WTSPEATAYR ; 850: KFTSASDVWS ; YGIVLWEVMS ; YGERPYWEMS ; NQDVIKAVDE ; GYRLPLPMDC ; 900: PAALYQLMLD ; CWQKDRNNRP ; KFEQIVSILD ; KLIRNPGSLK ; IITSAAARPS ; 950: NLLLDQSNVD ; IATFHTTGDW ; LNGMRTAHCK ; EIFTGVEYSS ; CDTIAKISTD ; 984: DMKKVGVTVV ; GPQKKIISSI ; KALETQSKNG ; PVPV
Sequence Length	984
String	O08680
Sub Unit	Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding by ADAM10 which regulates the EFNA5-EPHA3 complex internalization and function. Interacts (phosphorylated) with PTPN1; dephosphorylates EPHA3 and may regulate its trafficking and function. Interacts (phosphorylated) with CRK; mediates EFNA5-EPHA3 signaling through RHOA GTPase activation. Interacts with NCK1 (via SH2 domain); mediates EFNA5-EPHA3 signaling.

Uniprot	O08680
Gene Name	Epha3
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:29210
Unigene	Rn.10713

Reference	1. "IL-1 beta alters the expression of the receptor tyrosine kinase gene r-EphA3 in neonatal rat cardiomyocytes." Li Y.Y., McTiernan C.F., Feldman A.M. Am. J. Physiol.274:H331-H341(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Sprague-Dawley.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13804179	E1114r	96T	$796		Add to Cart

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