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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

SKU : BHE13804436

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1032r
Alternative Names	Phosphodiesterase I/nucleotide pyrophosphatase 1 ; Plasma-cell membrane glycoprotein PC-1 ; Npps ; Pc1 ; Pdnp1
Categories	Elisa
Function	Involved primarily in ATP hydrolysis at the plasma membrane. Plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. In vitro, has a broad specificity, hydrolyzing other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity.
Specificity	Natural and recombinant Rat Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
Subcellular Location	Membrane Single-pass type II membrane protein Targeted to the basolateral membrane in polarized epithelial cells and in hepatocytes, and to matrix vesicles in osteoblasts. In bile duct cells and cancer cells, located to the apical cytoplasmic side.
Detection Range	31.2-2000pg/mL
Entryname	ENPP1_RAT
Method Type	Sandwich
Platform	PF01223
Protein Name	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
Sensitivity	15.67pg/mL
Sequence	50: MERDGEQAGQ ; GPRHGPAGNG ; RELESPAAAS ; LLAPMDLGEE ; PLEKAERART ; 100: AKDPNTYKVL ; SLVLSVCVLT ; TILGCIFGLK ; PSCAKEVKSC ; KGRCFERTFS ; 150: NCRCDAACVS ; LGNCCLDFQE ; TCVEPTHIWT ; CNKFRCGEKR ; LSRFVCSCAD ; 200: DCKAHNDCCI ; NYSSVCQEKK ; SWVEEACETI ; DAPQCPAEFE ; SPPTLLFSLD ; 250: GFRAEYLHTW ; GGLLPVISKL ; KNCGTYTKNM ; RPVYPTKTFP ; NHYSIVTGLY ; 300: PESHGIIDNK ; MYDPKMNASF ; SLKSKEKFNP ; LWYKGQPIWV ; TANHQEVRSG ; 350: TYFWPGSDVE ; IDGILPDIYK ; VYNGSVPFEE ; RILAVLEWLQ ; LPSYERPHFY ; 400: TLYLEEPDSS ; GHSHGPVSSE ; VIKALQKVDH ; IVGMLMDGLK ; DLGLDKCLNL ; 450: ILISDHGMEQ ; GSCKKYVYLN ; KYLGDVNNVK ; VVYGPAARLR ; PTEVPETYYS ; 500: FNYEALAKNL ; SCRETNQHFR ; PYLKHFLPKR ; LHFAKNDRIE ; PLTFYLDPQW ; 550: QLALNPSERK ; YCGSGFHGSD ; NLFSNMQALF ; IGYGPAFKHG ; AEVDSFENIE ; 600: VYNLMCDLLG ; LIPAPNNESH ; GSLNHLLKKP ; IYTPSHPKEE ; SFLSQCPIKS ; 650: VSSDLGCTCD ; PSIVPIMDFE ; KQFNLTTDAV ; EDVYSMTVPN ; GRPRNLQKQH ; 700: RVCLLHQQQF ; LTGYSLDLLM ; PLWTSYTFLS ; NDQFSTDDFS ; NCLYQDLRIP ; 750: LSPMHKCSYY ; KSTSKLSYGF ; LTPPRLNRVS ; RQIYSEALLT ; SNIVPMYQSF ; 800: QVIWQYLHDT ; VLRRYAQERN ; GVNVVSGPVF ; DFDYDGRYDS ; SEILKQNTRV ; 850: IRSQENLIPT ; HFFIVLTSCK ; QLSESPLKCT ; ALESSAFLLP ; HRPDNIESCT ; 900: HGKQESAWVE ; ELLALHRARV ; TDVELITGLS ; FYQDRQESVS ; ELLRLKTHLP ; 906: IFSQED
Sequence Length	906
String	Q924C3
Sub Unit	Homodimer; disulfide-linked.

Uniprot	Q924C3
Gene Name	Enpp1
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:85496
Unigene	Rn.1199

Reference	1. "Structural basis of allotypes of ecto-nucleotide pyrophosphatase/phosphodiesterase (plasma cell membrane glycoprotein PC-1) in the mouse and rat, and analysis of allele-specific xenogeneic antibodies." Banakh I., Sali A., Dubljevic V., Grobben B., Slegers H., Goding J.W. Eur. J. Immunogenet.29:307-313(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);VARIANTS strain: Lewis. strain: Louvain. strain: Wistar. 2. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites." Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A. Proc. Natl. Acad. Sci. U.S.A.103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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