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ELISA Kit for Rat E3 ubiquitin-protein ligase HUWE1

SKU : BHE13812157

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2369r
Alternative Names	HECT ; UBA and WWE domain-containing protein 1 ; HECT-type E3 ubiquitin transferase HUWE1 ; Upstream regulatory element-binding protein 1 ; URE-B1 ; Ureb1
Categories	Elisa
Function	E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (By similarity). Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation.
Specificity	Natural and recombinant Rat E3 ubiquitin-protein ligase HUWE1
Subcellular Location	Cytoplasm Nucleus Mainly expressed in the cytoplasm of most tissues, except in the nucleus of spermatogonia, primary spermatocytes and neuronal cells.
Detection Range	0.78-50ng/mL
Entryname	HUWE1_RAT
Method Type	Competitive
Platform	PF00632
Protein Name	E3 ubiquitin-protein ligase HUWE1
Sensitivity	0.406ng/mL
Sequence	50: EEGQDAGGLL ; REWYMIISRE ; MFNPMYALFR ; TSPGDRVTYT ; INPSSHCNPN ; 100: HLSYFKFVGR ; IVAKAVYDNR ; LLECYFTRSF ; YKHILGKSVR ; YTDMESEDYH ; 150: FYQGLVYLLE ; NDVSTLGYDL ; TFSTEVQEFG ; VCEVRDLKPN ; GANILVTEEN ; 200: KKEYVHLVCQ ; MRMTGAIRKQ ; LAAFLEGFYE ; IIPKRLISIF ; TEQELELLIS ; 250: GLPTIDIDDL ; KSNTEYHKYQ ; SNSIQIQWFW ; RALRSFDQAD ; RAKFLQFVTG ; 300: TSKVPLQGFA ; ALEGMNGIQK ; FQIHRDDRST ; DRLPSAHTCF ; NQLDLPAYES ; 322: FEKLRHMLLL ; AIQECSEGFG ; LA
Sequence Length	322
String	P51593
Sub Unit	Interacts with isoform p19ARF of CDKN2A which strongly inhibits HUWE1 ubiquitin ligase activity (By similarity). Interacts with MYCN, POLB and CDC6.

Uniprot	P51593
Gene Name	Huwe1
Immunogen Species	Rattus norvegicus (Rat)
Unigene	Rn.12130

Reference	1. "Cloning of a DNA binding protein that is a tyrosine kinase substrate and recognizes an upstream initiator-like sequence in the promoter of the preprodynorphin gene." Gu J., Ren K., Dubner R., Iadarola M.J. Brain Res. Mol. Brain Res.24:77-88(1994) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION tissue: Brain. 2. "UREB1, a tyrosine phosphorylated nuclear protein, inhibits p53 transactivation." Gu J., Dubner R., Fornace A.J. Jr., Iadarola M.J. Oncogene11:2175-2178(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT TYR-219;MUTAGENESIS OF TYR-219 3. "Regulated expression of the ubiquitin protein ligase, E3(Histone)/LASU1/Mule/ARF-BP1/HUWE1, during spermatogenesis." Liu Z., Miao D., Xia Q., Hermo L., Wing S.S. Dev. Dyn.236:2889-2898(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;DEVELOPMENTAL STAGE

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SKU	Supplier No.	Size	Your price	Quantity
BHE13812157	E2369r	96T	$796		Add to Cart

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