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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat E3 ubiquitin-protein ligase HACE1

SKU : BHE13805920

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E4918r
Alternative Names	HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1 ; HECT-type E3 ubiquitin transferase HACE1
Categories	Elisa
Function	E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.
Specificity	Natural and recombinant Rat E3 ubiquitin-protein ligase HACE1
Subcellular Location	Golgi apparatus Golgi stack membrane Cytoplasm Endoplasmic reticulum A significant portion localizes to the endoplasmic reticulum. Targeted to Golgi membrane via its interaction with Rab proteins.
Detection Range	0.312-20ng/mL
Entryname	HACE1_RAT
Method Type	Sandwich
Platform	PF12796
Protein Name	E3 ubiquitin-protein ligase HACE1
Sensitivity	0.172ng/mL
Sequence	50: MERAMEQLNR ; LTRSLRRART ; VELPEDNETA ; VYTLMPMVMA ; DQHRSVSELL ; 100: SNSKFDVNYA ; FGRVKRSLLH ; IAANCGSVEC ; LVLLLKKGAN ; PNYQDISGCT ; 150: PLHLAARNGQ ; KKCMSKLLEY ; SADVNICNNE ; GLTAIHWLAV ; NGRTELLHDL ; 200: VQHVTDVDVE ; DAMGQTALHV ; ACQNGHKTTV ; QCLLDSGADI ; NRPNVAGATP ; 250: LYFACSHGQR ; DTAQILLLRG ; AKYLPDKNGV ; TPLDLCVQGG ; YGQTCEVLIQ ; 300: YHPRLFQTIV ; QMTQNEDLRE ; NMLRQVLQHL ; SQQSESQYLK ; ILTGLAEVAT ; 350: TNGHKLLSLS ; SSYEAQMKSL ; LRIVRIFCHV ; FRIGPSSPSN ; GMDMGYNGNK ; 400: TPRSQVFKPL ; ELLWHSLDEW ; LVLIATELMK ; NKEDSADITS ; ILLKQKGQDQ ; 450: EASCISAFEP ; PGPGSYERLS ; TGPGESKPDV ; LAGKQEASAD ; CQDVISVTAN ; 500: RLSAVIQAFY ; MCCSCQMPPG ; MTSPRFIEFV ; CKHDEVLKCF ; VNRNPKIIFD ; 550: HFHFLLECPE ; LMSRFMHIIK ; AQPFKDRCEW ; FYEHLHSGQP ; DSDMVHRPVS ; 600: ENDILLVHRD ; SIFRSSCEIV ; SKANCAKLKQ ; GIAVRFHGEE ; GMGQGVVREW ; 650: FDILSNEIVN ; PDYALFTQSA ; DGTTFQPNSN ; SYVNPDHLNY ; FRFAGQILGL ; 700: ALNHRQLVNI ; YFTRSFYKHI ; LGIPVNYQDV ; ASIDPEYAKN ; LQWILDNDIS ; 750: DLGLELTFSV ; ETDVFGAMEE ; VPLKPGGGSI ; LVTQNNKAEY ; VQLVTELRMT ; 800: RAIQPQINAF ; LQGFHMFIPP ; SLIQLFDEYE ; LELLLSGMPE ; IDVNDWIKNT ; 850: EYTSGYERED ; PVIQWFWEVV ; EDMTQEERVL ; LLQFVTGSSR ; VPHGGFANIM ; 900: GGSGLQNFTI ; AAVPYTPNLL ; PTSSTCINML ; KLPEYPSKEI ; LKDRLLVALH ; 909: CGSYGYTMA
Sequence Length	909
Sub Unit	Interacts with RARB. Interacts with RAB1 (RAB1A, RAB1B or RAB1C), RAB4 (RAB4A or RAB4B) and RAB11 (RAB11A or RAB11B); in a GTP-dependent manner. Interacts with RAC1; in a GTP-dependent manner. Interacts with the 26S proteasomal complex through the 20S core proteasomal subunit.

Uniprot	D3ZBM7
Gene Name	Hace1
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:361866
Unigene	Rn.28116

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805920	E4918r	96T	$796		Add to Cart

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