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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat E3 SUMO-protein ligase PIAS3

SKU : BHE13808375

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1591r
Alternative Names	KChAP ; Potassium channel-associated protein ; Protein inhibitor of activated STAT protein 3
Categories	Elisa
Function	Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context.
Specificity	Natural and recombinant Rat E3 SUMO-protein ligase PIAS3
Subcellular Location	Nucleus speckle
Detection Range	78-5000pg/mL
Entryname	PIAS3_RAT
Method Type	Sandwich
Platform	PF02891
Protein Name	E3 SUMO-protein ligase PIAS3
Sensitivity	41.3pg/mL
Sequence	50: MAELGELKHM ; VMSFRVSELQ ; VLLGFAGRNK ; SGRKHELLAK ; ALHLLKSSCA ; 100: PSVQMKIKEL ; YRRRFPRKTL ; GPSDLSLLSL ; PPGTSPVGSP ; SPLASIPPTL ; 150: LTPGTLLGPK ; REVDMHPPLP ; QPVHPDVTMK ; PLPFYEVYGE ; LIRPTTLAST ; 200: SSQRFEEAHF ; TFALTPQQLQ ; QILTSREVLP ; GAKCDYTIQV ; QLRFCLCETS ; 250: CPQEDYFPPN ; LFVKVNGKLC ; PLPGYLPPTK ; NGAEPKRPSR ; PINITPLARL ; 300: SATVPNTIVV ; NWSSEFGRNY ; SLSVYLVRQL ; TAGTLLQKLR ; AKGIRNPDHS ; 350: RALIKEKLTA ; DPDSEVATTS ; LRVSLMCPLG ; KMRLTVPCRA ; LTCAHLQSFD ; 400: AALYLQMNEK ; KPTWTCPVCD ; KKAPYESLII ; DGLFMEILNS ; CSDCDEIQFM ; 450: EDGSWCPMKP ; KKEASEVCPP ; PGYGLDGLQY ; SPVQEGNQSE ; NKKRVEVIDL ; 500: TIESSSDEED ; LPPTKKHCPV ; TSAAIPALPG ; SKGALTSGHQ ; PSSVLRSPAM ; 550: GTLGSDFLSS ; LPLHEYPPAF ; PLGADIQGLD ; LFSFLQTESQ ; HYSPSVITSL ; 600: DEQDTLGHFF ; QFRGTPPHFL ; GPLAPTLGSS ; HRSATPAPAP ; GRVSSIVAPG ; 628: SSLREGHGGP ; LPSGPSLTGC ; RSDVISLD
Sequence Length	628
String	O70260
Sub Unit	Binds SUMO1 and UBE2I. Interacts with AR, BCL11A, GFI1, HMGA2, IRF1, MITF, NCOA2, as well as with STAT3, after treatment with IL6, CNTF or OSM and with STAT5, after PRL stimulation. Interacts with PLAG1 (By similarity). Interacts with ZFHX3.

Uniprot	O70260
Gene Name	Pias3
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:83614
Unigene	Rn.14548

Reference	1. "Cloning and expression of a novel K+ channel regulatory protein, KChAP." Wible B.A., Yang Q., Kuryshev Y.A., Accili E.A., Brown A.M. J. Biol. Chem.273:11745-11751(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION;TISSUE SPECIFICITY tissue: Brain. 2. "A new role for the STAT3 inhibitor, PIAS3: a repressor of microphthalmia transcription factor." Levy C., Nechushtan H., Razin E. J. Biol. Chem.277:1962-1966(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MITF 3. "The intranuclear prolactin/cyclophilin B complex as a transcriptional inducer." Rycyzyn M.A., Clevenger C.V. Proc. Natl. Acad. Sci. U.S.A.99:6790-6795(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STAT5

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808375	E1591r	96T	$796		Add to Cart

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