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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Dynein light chain 1, cytoplasmic

SKU : BHE13803202

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E13866r
Alternative Names	8 kDa dynein light chain ; DLC8 ; Dynein light chain LC8-type 1 ; Protein inhibitor of neuronal nitric oxide synthase ; PIN ; Dncl1 ; Dnclc1 ; Pin
Categories	Elisa
Function	Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.
Specificity	Natural and recombinant Rat Dynein light chain 1, cytoplasmic
Subcellular Location	Cytoplasm cytoskeleton Nucleus Mitochondrion Associated with microtubules.
Entryname	DYL1_RAT
Platform	PF01221
Protein Name	Dynein light chain 1, cytoplasmic
Sequence	50: MCDRKAVIKN ; ADMSEEMQQD ; SVECATQALE ; KYNIEKDIAA ; HIKKEFDKKY ; 89: NPTWHCIVGR ; NFGSYVTHET ; KHFIYFYLGQ ; VAILLFKSG
Sequence Length	89
String	P63170
Sub Unit	Homodimer. Monomer; the monomeric form is incapable of binding to target proteins. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with TXNDC17. Interacts with WWC1 and ESR1. The interaction with WWC1 is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin. Interacts with BCL2L11. Interacts with BCL2; the interaction is greatly enhanced in the nucleus and in mitochondria upon induction of apoptosis. Interacts with PAK1; the interaction requires dimeric DYNLL1 (By similarity). Interacts with rabies virus phosphoprotein. Interacts with GCOM1.

Uniprot	P63170
Gene Name	Dynll1
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:58945
Unigene	Rn.35769

Reference	1. "PIN: an associated protein inhibitor of neuronal nitric oxide synthase." Jaffrey S.R., Snyder S.H. Science274:774-777(1996) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. "Distribution of protein inhibitor of neuronal nitric oxide synthase in rat brain." Greenwood M.T., Guo Y., Kumar U., Beausejours S., Hussain S.N.A. Biochem. Biophys. Res. Commun.238:617-621(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Pituitary. 4. Lubec G., Afjehi-Sadat L. Submitted (2006-11) to the UniProtKB [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 50-60;IDENTIFICATION BY MASS SPECTROMETRY strain: Sprague-Dawley. tissue: Spinal cord. 5. "Brain cytoplasmic and flagellar outer arm dyneins share a highly conserved Mr 8,000 light chain." King S.M., Barbarese E., Dillman J.F. III, Patel-King R.S., Carson J.H., Pfister K.K. J. Biol. Chem.271:19358-19366(1996) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE CYTOPLASMIC DYNEIN 1 COMPLEX;SUBCELLULAR LOCATION 6. "Light chains of mammalian cytoplasmic dynein: identification and characterization of a family of LC8 light chains." Wilson M.J., Salata M.W., Susalka S.J., Pfister K.K. Cell Motil. Cytoskeleton49:229-240(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE CYTOPLASMIC DYNEIN 1 COMPLEX 7. "Molecular basis for the interaction between rabies virus phosphoprotein P and the dynein light chain LC8: dissociation of dynein-binding properties and transcriptional functionality of P." Poisson N., Real E., Gaudin Y., Vaney M.C., King S., Jacob Y., Tordo N., Blondel D. J. Gen. Virol.82:2691-2696(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RABIES VIRUS PHOSPHOPROTEIN 8. "Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection." Thompson S., Pearson A.N., Ashley M.D., Jessick V., Murphy B.M., Gafken P., Henshall D.C., Morris K.T., Simon R.P., Meller R. J. Biol. Chem.286:19331-19339(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BCL2L11 9. "Structural basis of diverse sequence-dependent target recognition by the 8 kDa dynein light chain." Fan J.-S., Zhang Q., Tochio H., Li M., Zhang M. J. Mol. Biol.306:97-108(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR

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