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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Double-stranded RNA-specific adenosine deaminase

SKU : BHE13803658

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E10803r
Alternative Names	Dsrad
Categories	Elisa
Function	Converts multiple adenosines to inosines and creates I/U mismatched base pairs in double-helical RNA substrates without apparent sequence specificity. DRADA has been found to modify more frequently adenosines in AU-rich regions, probably due to the relative ease of melting A/U base pairs as compared to G/C pairs. Functions to modify viral RNA genomes and may be responsible for hypermutation of certain negative-stranded viruses. Edits the messenger RNAs for glutamate receptor (GLUR) subunits by site-selective adenosine deamination. Produces low-level editing at the GLUR-B Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Binds to short interfering RNAs (siRNA) without editing them and suppresses siRNA-mediated RNA interference. Binds to ILF3/NF90 and up-regulates ILF3-mediated gene expression.
Specificity	Natural and recombinant Rat Double-stranded RNA-specific adenosine deaminase
Subcellular Location	Cytoplasm Nucleus nucleolus
Detection Range	0.312-20ng/mL
Entryname	DSRAD_RAT
Method Type	Sandwich
Platform	PF02137
Protein Name	Double-stranded RNA-specific adenosine deaminase
Sensitivity	0.188ng/mL
Sequence	50: MSQGFRGPTG ; VFPHQTQPCL ; DPSYEHSKWR ; YLQPRGSESY ; LRSFQLQQIE ; 100: FLKGRLPEAP ; LIGAQTQSLP ; PFLPGHWPRF ; PGPPAQGKQP ; EIWGFPRSVT ; 150: LRNQGFHIGP ; PLPPPHSRGP ; PWRGAEGLCS ; HFQELSISQN ; PEQKVLNRLE ; 200: ELGEGKATTA ; YALARELRTP ; KKDINRILYS ; LERKGKLHRG ; VGKPPLWSLV ; 250: PLSQACTQPP ; RAVNSDKEVP ; RGEPDLDSED ; GDPASDLEGP ; SELLDMAEIK ; 300: EKICDYLFNV ; SKSSALNLAK ; NIGLAKARDV ; NAVLIDLERQ ; GDVYREGATP ; 350: PIWYLTDKKR ; ERLQMKRSTH ; SGPAATPAAV ; SEATQSTSFP ; TCHPPQSGGS ; 400: SSMATSKRVE ; NGQEPVTKYE ; SRHEARPGPV ; RLRPHAYHNG ; PSRAGYVASE ; 450: NGPWATDDIP ; DNLNSIHTAP ; GEFRAIMEMP ; SFYSPTLPRC ; SPYKKLTECQ ; 500: LKNPVSGLLE ; YAQFTSQTCD ; FNLIEQSGPS ; HEPRFKFQVV ; INGREFPPAE ; 550: AGSKKVAKQD ; AAVKAMAILL ; REAKAKDSGQ ; PEELSNCPME ; EDPEKPAESQ ; 600: PPSSSATSLF ; SGKSPVTTLL ; ECMHKLGNSC ; EFRLLSKEGP ; AHDPKFQYCV ; 650: AVGAQTFPSV ; SAPSKKVAKQ ; MAAEEAMKAL ; QEEAANSADD ; QSGGANTDSL ; 700: DESVAPNKIR ; RIGELVRYLN ; TNPVGGLLEY ; ARSHGFAAEF ; KLIDQSGPPH ; 750: EPKFVYQAKV ; GGRWFPAVCA ; HSKKQGKQDA ; ADAALRVLIG ; ESEKAEQLGF ; 800: AEVTPVTGAS ; LRRTMLLLSR ; SPDAHPKTLP ; LTGSTFHDQI ; AMLSHRCFNA ; 850: LTNSFQPSLL ; GRKILAAIIM ; KRDPEDMGVV ; VSLGTGNRCV ; KGDSLSLKGE ; 900: TVNDCHAEII ; SRRGFIRFLY ; SELMKYNHHT ; AKNSIFELAR ; GGEKLQIKKT ; 950: VSFHLYISTA ; PCGDGAHFDK ; SCSDRAVEST ; ESRHYPVFEN ; PKQGKLRTKV ; 1000: ENGEGTIPVE ; SSDIVPTWDG ; IRLGERLRTM ; SCSDKILRWN ; VLGLQGALLT ; 1050: HFLQPVYLKS ; VTLGYLFSQG ; HLTRAICCRV ; TRDGNAFEDG ; LRYPFIVNHP ; 1100: KVGRVSVYDS ; KRQSGKTKET ; SVNWCLADGY ; DLEILDGTRG ; TVDGPGKELS ; 1150: RVSKKNIFLQ ; FKKLCSFRAR ; RDLLQLSYGE ; AKKAARDYDL ; AKNYFKKSLR ; 1175: DMGYGNWISK ; PQEEKNFYLC ; PVPND
Sequence Length	1175
String	P55266
Sub Unit	Homodimer. Interacts with ILF2/NF45 and ILF3/NF90.

Uniprot	P55266
Gene Name	Adar
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:81635
Unigene	Rn.10056

Reference	1. "Cloning of cDNAs encoding mammalian double-stranded RNA-specific adenosine deaminase." O'Connell M.A., Krause S., Higuchi M., Hsuan J.J., Totty N.F., Jenny A., Keller W. Mol. Cell. Biol.15:1389-1397(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Wistar. tissue: Brain.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13803658	E10803r	96T	$796		Add to Cart

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