ELISA Kit for Rat Deoxyuridine 5'-triphosphate nucleotidohydrolase

Mfr.No.	E1549r
Alternative Names	PPAR-interacting protein 4 ; PIP4 ; dUTP pyrophosphatase ; Dutp
Categories	Elisa
Function	This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor.
Specificity	Natural and recombinant Rat Deoxyuridine 5'-triphosphate nucleotidohydrolase
Subcellular Location	Cytoplasm Nucleus Binding to PPAR induces translocation to the nucleus.
Detection Range	78-5000pg/ml
Entryname	DUT_RAT
Method Type	Sandwich
Platform	PF00692
Protein Name	Deoxyuridine 5'-triphosphate nucleotidohydrolase
Sensitivity	40pg/mL
Sequence	50: MPLLCALLRS ; RLQPSLLRSL ; TLTSAQSLSC ; GGSRGVRTWS ; ARTGPGACAD ; 100: PAVSVSKRAR ; AEDDASLRFV ; RLSEHATAPT ; RGSARAAGYD ; LYSAYDYTIP ; 150: SMEKALVKTD ; IQIAVPSGCY ; GRVAPRSGLA ; VKHFIDVGAG ; VIDEDYRGNV ; 200: GVVLFNFGKE ; KFEVKKGDRI ; AQLICERILY ; PDLEEVQTLD ; NTERGSGGFG ; 205: STGKN
Sequence Length	205
String	P70583

Reference	1. "Cloning and identification of rat deoxyuridine triphosphatase as an inhibitor of peroxisome proliferator-activated receptor alpha." Chu R.Y., Lin Y.L., Rao M.S., Reddy J.K. J. Biol. Chem.271:27670-27676(1996) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Sprague-Dawley. tissue: Liver. 2. Chu R.Y., Lin Y.L., Rao M.S., Reddy J.K. Submitted (1999-09) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION

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