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ELISA Kit for Rat D(2) dopamine receptor

SKU : BHE13803606

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0673r
Alternative Names	Dopamine D2 receptor
Categories	Elisa
Function	Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.
Specificity	Natural and recombinant Rat D(2) dopamine receptor
Subcellular Location	Cell membrane Multi-pass membrane protein
Detection Range	0.156-10ng/mL
Entryname	DRD2_RAT
Method Type	Sandwich
Platform	PF00001
Protein Name	D(2) dopamine receptor
Sensitivity	0.081ng/mL
Sequence	50: MDPLNLSWYD ; DDLERQNWSR ; PFNGSEGKAD ; RPHYNYYAML ; LTLLIFIIVF ; 100: GNVLVCMAVS ; REKALQTTTN ; YLIVSLAVAD ; LLVATLVMPW ; VVYLEVVGEW ; 150: KFSRIHCDIF ; VTLDVMMCTA ; SILNLCAISI ; DRYTAVAMPM ; LYNTRYSSKR ; 200: RVTVMIAIVW ; VLSFTISCPL ; LFGLNNTDQN ; ECIIANPAFV ; VYSSIVSFYV ; 250: PFIVTLLVYI ; KIYIVLRKRR ; KRVNTKRSSR ; AFRANLKTPL ; KGNCTHPEDM ; 300: KLCTVIMKSN ; GSFPVNRRRM ; DAARRAQELE ; MEMLSSTSPP ; ERTRYSPIPP ; 350: SHHQLTLPDP ; SHHGLHSNPD ; SPAKPEKNGH ; AKIVNPRIAK ; FFEIQTMPNG ; 400: KTRTSLKTMS ; RRKLSQQKEK ; KATQMLAIVL ; GVFIICWLPF ; FITHILNIHC ; 444: DCNIPPVLYS ; AFTWLGYVNS ; AVNPIIYTTF ; NIEFRKAFMK ; ILHC
Sequence Length	444
String	P61169
Sub Unit	Forms homo- and heterooligomers with DRD4. The interaction with DRD4 may modulate agonist-induced downstream signaling (By similarity). Interacts with GNAI1, CADPS and CADPS2 (By similarity). Interacts with GPRASP1, PPP1R9B and CLIC6. Interacts with ARRB2.

Uniprot	P61169
Gene Name	Drd2
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:24318
Unigene	Rn.87299

Reference	1. "Cloning and expression of a rat D2 dopamine receptor cDNA." Bunzow J.R., van Tol H.H.M., Grandy D.K., Albert P., Salon J., Christie M., Machida C.A., Neve K.A., Civelli O. Nature336:783-787(1988) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT) tissue: Brain. 2. "D2 receptor, a missing exon." Eidne K.A., Taylor P.L., Zabavnik J., Saunders P.T.K., Inglis J.D. Nature342:865-865(1989) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 3. "Alternative splicing directs the expression of two D2 dopamine receptor isoforms." Giros B., Sokoloff P., Martres M.-P., Riou J.-F., Emorine L.J., Schwartz J.-C. Nature342:923-926(1989) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 4. "Multiple D2 dopamine receptors produced by alternative RNA splicing." Monsma F.J. Jr., McVittie L.D., Gerfen C.R., Mahan L.C., Sibley D.R. Nature342:926-929(1989) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 5. "Two forms of the rat D2 dopamine receptor as revealed by the polymerase chain reaction." Rao D.D., McKelvy J., Kebabian J., MacKenzie R.G. FEBS Lett.263:18-22(1990) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 6. "5'untranslated region of rat pituitary dopamine D2(B) receptor contains a putative CpG island." Taylor P.L., Inglis J.D., Eidne K.A. Submitted (1990-10) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG) strain: Sprague-Dawley. 7. "Identification by sequence analysis of a second rat brain cDNA encoding the dopamine (D2) receptor." Miller J.C., Wang Y., Filer D. Biochem. Biophys. Res. Commun.166:109-112(1990) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 242-270 8. "Cloning of two additional catecholamine receptors from rat brain." O'Dowd B.F., Nguyen T., Tirpak A., Jarvie K.R., Israel Y., Seeman P., Niznik H.B. FEBS Lett.262:8-12(1990) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 242-270 9. "Contributions of conserved serine residues to the interactions of ligands with dopamine D2 receptors." Cox B.A., Henningsen R.A., Spanoyannis A., Neve R.L., Neve K.A. J. Neurochem.59:627-635(1992) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF SER-193; SER-194; SER-197 AND SER-420 10. "Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein." Smith F.D., Oxford G.S., Milgram S.L. J. Biol. Chem.274:19894-19900(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPP1R9B 11. "CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors." Griffon N., Jeanneteau F., Prieur F., Diaz J., Sokoloff P. Brain Res. Mol. Brain Res.117:47-57(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CLIC6 12. "Dopamine responsiveness is regulated by targeted sorting of D2 receptors." Bartlett S.E., Enquist J., Hopf F.W., Lee J.H., Gladher F., Kharazia V., Waldhoer M., Mailliard W.S., Armstrong R., Bonci A., Whistler J.L. Proc. Natl. Acad. Sci. U.S.A.102:11521-11526(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GPRASP1 13. "G protein-coupled receptor kinase-mediated phosphorylation regulates post-endocytic trafficking of the D2 dopamine receptor." Namkung Y., Dipace C., Javitch J.A., Sibley D.R. J. Biol. Chem.284:15038-15051(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARRB2 14. "Molecular modelling of D2-like dopamine receptors." Livingstone C.D., Strange P.G., Naylor L.H. Biochem. J.287:277-282(1992) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING

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