Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
Specificity
Natural and recombinant Rat Cytochrome c oxidase subunit 1
Subcellular Location
Mitochondrion inner membrane Multi-pass membrane protein
"Analysis of a DNA segment from rat liver mitochondria containing the genes for the cytochrome oxidase subunits I, II, II, ATPase subunit 6, and several tRNA genes." Grosskopf R., Feldmann H. Curr. Genet.4:151-158(1981)
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