ELISA Kit for Rat Complement C1q subcomponent subunit C

Mfr.No.	E0339r
Alternative Names	C1qg
Categories	Elisa
Function	C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
Specificity	Natural and recombinant Rat Complement C1q subcomponent subunit C
Subcellular Location	Secreted
Detection Range	12.5-800ng/mL
Entryname	C1QC_RAT
Method Type	Sandwich
Platform	PF00386
Protein Name	Complement C1q subcomponent subunit C
Sensitivity	10ng/mL
Sequence	50: MVVGTSCQPQ ; HGLYLLLLLL ; ALPLRSQANA ; GCYGIPGMPG ; LPGTPGKDGH ; 100: DGLQGPKGEP ; GIPAIPGTQG ; PKGQKGEPGM ; PGHRGKNGPM ; GTSGSPGDPG ; 150: PRGPPGEPGE ; EGRYKQKHQS ; VFTVTRQTAQ ; YPAANGLVKF ; NSAITNPQGD ; 200: YNTNTGKFTC ; KVPGLYYFVH ; HTSQTANLCV ; QLLLNNAKVT ; SFCDHMSNSK ; 245: QVSSGGVLLR ; LQRGDEVWLA ; VNDYNGMVGT ; EGSDSVFSGF ; LLFPD
Sequence Length	245
String	P31722
Sub Unit	C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. C1q subcomponent is composed of nine subunits, six of which are disulfide-linked dimers of the a and B chains, and three of which are disulfide-linked dimers of the C chain. In addition to the major A:B and C:C dimer bands, rat, unlike human C1q, contained minor dimer species.

Reference	1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Ovary. 2. "Rapid isolation and biochemical characterization of rat C1 and C1q." Wing M.G., Seilly D.J., Bridgman D.J., Harrison R.A. Mol. Immunol.30:433-440(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 29-56

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