ELISA Kit for Rat Cold-inducible RNA-binding protein

Mfr.No.	E12931r
Alternative Names	A18 hnRNP ; Glycine-rich RNA-binding protein CIRP ; Cirp
Categories	Elisa
Function	Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor. Promotes assembly of stress granules (SGs), when overexpressed.
Specificity	Natural and recombinant Rat Cold-inducible RNA-binding protein
Subcellular Location	Nucleus nucleoplasm Cytoplasm Translocates from the nucleus to the cytoplasm after exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins.
Detection Range	78-5000pg/ml
Entryname	CIRBP_RAT
Method Type	Sandwich
Platform	PF00076
Protein Name	Cold-inducible RNA-binding protein
Sensitivity	39.3pg/mL
Sequence	50: MASDEGKLFV ; GGLSFDTNEQ ; ALEQVFSKYG ; QISEVVVVKD ; RETQRSRGFG ; 100: FVTFENIDDA ; KDAMMAMNGK ; SVDGRQIRVD ; QAGKSSDNRS ; RGYRGGSAGG ; 150: RGFFRGGRSR ; GRGFSRGGGD ; RGYGGGRFES ; RSGGYGGSRD ; YYASRSQGGS ; 172: YGYRSSGGSY ; RDSYDSYATH ; NE
Sequence Length	172
String	P60825
Sub Unit	Interacts with EIF4G1. Associates with ribosomes.

Reference	1. "Expression of cold inducible-RNA-binding protein (CIRP) in the rat brain." Xue J., Nishiyama H., Fujita J. Submitted (1997-01) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Wistar. tissue: Testis.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13802040	E12931r	96T	$796		Add to Cart