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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Calcium release-activated calcium channel protein 1

SKU : BHE13803368

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15347r
Alternative Names	Protein orai-1 ; Transmembrane protein 142A ; Cracm1 ; Tmem142a
Categories	Elisa
Function	Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT.
Specificity	Natural and recombinant Rat Calcium release-activated calcium channel protein 1
Subcellular Location	Cell membrane Multi-pass membrane protein
Detection Range	0.156-10ng/mL
Entryname	CRCM1_RAT
Method Type	Sandwich
Platform	PF07856
Protein Name	Calcium release-activated calcium channel protein 1
Sensitivity	0.06ng/mL
Sequence	50: MHPEPAPPPN ; NSNPELPLSG ; GSSTSGSRRS ; RRRSGDGEPT ; GAPPLPPPPA ; 100: VSYPDWIGQS ; YSEVMSLNEH ; SMQALSWRKL ; YLSRAKLKAS ; SRTSALLSGF ; 150: AMVAMVEVQL ; DTDHDYPPGL ; LIVFSACTTV ; LVAVHLFALM ; ISTCILPNIE ; 200: AVSNVHNLNS ; VKESPHERMH ; RHIELAWAFS ; TVIGTLLFLA ; EVVLLCWVKF ; 250: LPLKRQAGQP ; SPTKPPTEPA ; VVVANSSNNG ; GITPGEAAAI ; ASTAIMVPCG ; 300: LVFIVFAVHF ; YRSLVSHKTD ; RQFQELNELA ; EFARLQDQLD ; HRGDHSLTPG ; 304: THYA
Sequence Length	304
String	Q5M848
Sub Unit	Interacts with STIM1 and STIM2. Interacts with EFCAB4B/CRACR2A; the interaction is direct and takes place in absence of Ca(2+). Forms a complex with EFCAB4B/CRACR2A and STIM1 at low concentration of Ca(2+), the complex dissociates at elevated Ca(2+) concentrations.

Uniprot	Q5M848
Gene Name	Orai1
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:304496
Unigene	Rn.3869

Reference	1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Liver. 2. "Crystal structure of calmodulin binding domain of orai1 in complex with Ca2+ calmodulin displays a unique binding mode." Liu Y., Zheng X., Mueller G.A., Sobhany M., DeRose E.F., Zhang Y., London R.E., Birnbaumer L. J. Biol. Chem.287:43030-43041(2012) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ORAI1

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SKU	Supplier No.	Size	Your price	Quantity
BHE13803368	E15347r	96T	$796		Add to Cart

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