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ELISA Kit for Rat C-type mannose receptor 2

SKU : BHE13807879

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2105r
Alternative Names	Endocytic receptor 180 ; Macrophage mannose receptor 2 ; CD280 ; Endo180
Categories	Elisa
Function	May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices (By similarity). May participate in remodeling of extracellular matrix co-operating with the matrix metalloproteinases (MMPs) secreted by hepatic stellate cells. May mediate endocytosis of partially degraded collagens and glycoproteins produced in the extracellular matrix by MMPs.
Specificity	Natural and recombinant Rat C-type mannose receptor 2
Subcellular Location	Cell membrane Single-pass membrane protein
Detection Range	0.156-10ng/mL
Entryname	MRC2_RAT
Method Type	Sandwich
Platform	PF00040
Protein Name	C-type mannose receptor 2
Sensitivity	0.078ng/mL
Sequence	50: MGPIRPALAP ; WPRHLLRCVL ; LLGGLRLGHP ; ADSAAALLEP ; DVFLIFSQGM ; 100: QGCLEAQGVQ ; VRVIPVCNAS ; LPAQRWKWVS ; RNRLFNLGAM ; QCLGTGWPAT ; 150: NTTVSLGMYE ; CDREALSLRW ; QCRTLGDQLS ; LLLGARANNA ; SKPGTLERGD ; 200: QTRSGHWNIY ; GSEEDLCARP ; YYEVYTIQGN ; SHGKPCTIPF ; KYDNQWFHGC ; 250: TSTGREDGHL ; WCATTQDYGK ; DERWGFCPIK ; SNDCETFWDK ; DQLTDSCYQF ; 300: NFQSTLSWRE ; AWASCEQQGA ; DLLSITEIHE ; QTYINGLLTG ; YSSTLWIGLN ; 350: DLDTSGGWQW ; SDNSPLKYLN ; WESDQPDNPG ; EENCGVIRTE ; SSGGWQNHDC ; 400: SIALPYVCKK ; KPNATAEPIQ ; PDRWANVKVE ; CDPSWQPFQG ; HCYRLQAEKR ; 450: SWQESKRACL ; RGGGDLLSIH ; SMTELEFITK ; QIKQEVEELW ; IGLNDLKLQM ; 500: NFEWSDGSLV ; SFTHWHPFEP ; NNFRDSLEDC ; VTIWGPEGRW ; NDSPCNQSLP ; 550: SICKKAGRLS ; QGTAEEDHGC ; RKGWTWHSPS ; CYWLGEDQVI ; YSDARRLCTD ; 600: HGSQLVTITN ; RFEQAFVSSL ; IYNWEGEYFW ; TALQDLNSTG ; SFRWLSGDEV ; 650: MYTHWNRDQP ; GYRRGGCVAL ; ATGSAMGLWE ; VKNCTSFRAR ; YICRQSLGTP ; 700: VTPELPGPDP ; TPSLTGSCPQ ; GWVSDPKLRH ; CYKVFSSERL ; QEKKSWIEAL ; 750: GVCRELGAQL ; LSLASYEEEH ; FVANMLNKIF ; GESEPENHEQ ; HWFWIGLNRR ; 800: DPREGHSWRW ; SDGLGFSYHN ; FARSQHDDDN ; IRGCAVLDLA ; SLQWVAMQCQ ; 850: TQLDWICKIP ; RGVDVREPDI ; GRQGRLEWVR ; FQEAEYKFFE ; HHSSWAQAQR ; 900: ICTWFQAELT ; SVHSQAELDF ; LGQNMQKLSS ; DQEQHWWIGL ; HTSESDGRFR ; 950: WSDGSVINFV ; SWAPGKPRPI ; GKDKKCVYMT ; ARQEDWGDQR ; CHTALPYICK ; 1000: RSNSSGETRP ; HDLPPSTLGG ; CPSGWNQFLN ; KCFRIQGQDP ; QDRVKWSEAQ ; 1050: FSCEQQEAQL ; VTIANPLEQA ; YITASLPNVT ; FDLWIGLHGS ; QRDFQWIEQE ; 1100: PLLYTNWAPG ; EPSGPSPAPS ; GTKPTSCAVI ; LHSPSAHFTG ; RWDDRSCTEE ; 1150: THGFICQKGT ; DPSLSPSPAA ; ALPAPGTELS ; YLNRTFRLLQ ; KPLRWKDALL ; 1200: LCESRNASLA ; HVPDPYTQAF ; LTQAARGLQA ; PLWIGLASEE ; GSRRYSWLSE ; 1250: EPLNYASWQD ; GEPQHTGGCA ; YVDVDGTWRT ; TSCDTKLQGA ; VCGVSRGPPP ; 1300: PRISYRGSCP ; QGLADSSWIP ; FREHCYSFHT ; ELLLGHKEAL ; QRCQRAGGTV ; 1350: LSILDEMENV ; FVWEHLQTAE ; TQSRGAWLGM ; NFNPKGGMLV ; WQDNTAVNYS ; 1400: NWGPPGLGPS ; MLSHNSCYWI ; QSSSGLWRPG ; ACTNVTMGVV ; CKLPRVEENG ; 1450: FLPSAALPEN ; PVALVVVLTA ; AVLLLLALLT ; GALILYRRRQ ; SAERGSFEGA ; 1480: RYSRSSRSGP ; AEATEKNILV ; SDMEMNEQQE ;
Sequence Length	1480
String	Q4TU93
Sub Unit	Interacts directly with PLAUR/UPAR and PLAU/pro-UPA to form a tri-molecular complex. Interacts with collagen V (By similarity). Interacts with C-terminal region of type I collagen/COL1A1.

Uniprot	Q4TU93
Gene Name	Mrc2
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:498011
Unigene	Rn.213511

Reference	1. "Endo180 binds to the C-terminal region of type I collagen." Thomas E.K., Nakamura M., Wienke D., Isacke C.M., Pozzi A., Liang P. J. Biol. Chem.280:22596-22605(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];IDENTIFICATION BY MASS SPECTROMETRY;GLYCOSYLATION;INTERACTION WITH COL1A1 strain: Sprague-Dawley. 2. "Uptake of denatured collagen into hepatic stellate cells: evidence for the involvement of urokinase plasminogen activator receptor-associated protein/Endo180." Mousavi S.A., Sato M., Sporstol M., Smedsrod B., Berg T., Kojima N., Senoo H. Biochem. J.387:39-46(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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SKU	Supplier No.	Size	Your price	Quantity
BHE13807879	E2105r	96T	$796		Add to Cart

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