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ELISA Kit for Rat Breast cancer type 2 susceptibility protein homolog

SKU : BHE13801388

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1364r
Alternative Names	Fanconi anemia group D1 protein homolog ; Fancd1
Categories	Elisa
Function	Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. In concert with NPM1, regulates centrosome duplication.
Specificity	Natural and recombinant Rat Breast cancer type 2 susceptibility protein homolog
Detection Range	0.156-10ng/ml
Entryname	BRCA2_RAT
Method Type	Sandwich
Platform	PF09169
Protein Name	Breast cancer type 2 susceptibility protein homolog
Sensitivity	0.095ng/mL
Sequence	50: MTVEYKRRPT ; FWEIFKARCS ; TADLGPISLN ; WFEELFSEAP ; PYNTEHPEES ; 100: EYKPQGHEPQ ; LFKTPQRNPS ; YHQFASTPIM ; FKEQSQTLPL ; DQSPFKELGN ; 150: VVANSKRKHH ; SKKKARKDPV ; VDVASLPLKA ; CPSESPCTPR ; CTQVAPQRRK ; 200: PVVSGSLFYT ; PKLEETPKHI ; SESLGVEVDP ; DMSWTSSLAT ; PPTLSSTVLI ; 250: ARDEEAHRNA ; FPADSPASLK ; SYFSNHNESL ; KKNDRFIPSV ; SDSENKSQQE ; 300: AFSQGLEKML ; GDSSSKINRF ; RDCLRKPIPN ; VLEDGETAVD ; TSGEDSFSLC ; 350: FPKRRTRNLQ ; KTRMGKMKKK ; IFSETRTDGL ; SEEARGQADD ; KNSFALEIEP ; 400: RDSEPLDPSV ; TNQKPLYSQS ; GDISSEAGQC ; SDSIWSQPDP ; SGLNGTQTRK ; 450: IPLLHISFHK ; QSILEDFIDM ; KKEGTGSITF ; PHISSLPEPE ; KMFSEETLVD ; 500: KEHEGQHLES ; LEDSISGKQM ; VSGTSQTACL ; SPSIRKSIVK ; MREPLEETLD ; 550: TVFSDSMTSS ; AFTEELDASA ; GGLEIHTACS ; QREDSLCPSS ; VDTGSWPTTL ; 600: TDTSATVKNA ; GLITTLKNKR ; RKFIYSVSDD ; ASHQGKKLQT ; QRQSELTNLS ; 650: APFEASAFEV ; PFPFTNVDSG ; IPDSSIKRSN ; LPNDPEEPSL ; SLTNSFVTAA ; 700: SKEISYIHAL ; ISQDLNDKEA ; ILSEEKPQPY ; TALEADFLSC ; LPERSCENDQ ; 750: KSPKVSDRKE ; KVLVSACRPS ; GRLAAAVQLS ; SISFDSQENP ; LGSHNVTSTL ; 800: KLTPSPKTPL ; SKPVVVSRGK ; MCKMPEKLQC ; KSCKDNIELS ; KNIPLGVNEM ; 850: CVLSENSETP ; ELLPPLEYIT ; EVSSSVKSQF ; NQNTKIAVVQ ; KDQKDSTFIS ; 900: EVTVHMNSEE ; LFPEKENNFA ; FQVTNESNKP ; NIGSTVEFQE ; EDLSHAKGHS ; 950: LKNSPMTVDR ; DLDDEQAGQV ; LITEDSDSLA ; VVHDCTKKSR ; NTIEQHQKGT ; 1000: ADKDFKSNSS ; LYLKSDGNND ; YLDKWSEFLD ; PLMNHKLGGS ; FRTASNKEIK ; 1050: LSEDNVKKSK ; MFFKDIEEQY ; PTSLDCIDTV ; STLQLANKKR ; LSEPHTFDLK ; 1100: SGTTVSTQCH ; SQSSVSHEDT ; HTAPQMLSSK ; QDFHSSHNLT ; PSQKAEITEL ; 1150: STILEESGSQ ; FEFTQFKNPS ; HIAQNNTSAV ; LGNQMAVVRT ; ASEEWKDVDL ; 1200: HLPLNPSSVG ; QIDHNKKFEC ; LVGVKQSSSH ; LLEDTCNQNT ; SCFLPIKEME ; 1250: FGGFCSALGT ; KLSVSNEALR ; KAMKLFSDIE ; NISEEPSTKV ; GPRGFSSCAH ; 1300: HDSVASVFKI ; KKQNTDKSFD ; EKSSKCQVTV ; QNNKEMTTCI ; LVDENPENYV ; 1350: KNIKQDNNYT ; GSQRNAYKLE ; NSDVSKSSTS ; GTVYINKGDS ; DLPFAAEKGN ; 1400: KYPESCTQYV ; REENAQIKES ; VSDLTCLEVM ; KAEETCHMKS ; SDKEQLPSDK ; 1450: MEQNMKEFNI ; SFQTASGKNI ; RVSKESLNKS ; VNILDQETED ; LTVTSDSLNS ; 1500: KILCGINKDK ; MHISCHKKSI ; NIKKVFEEHF ; PIGTVSQLPA ; LQQYPEYEIE ; 1550: SIKEPTLLSF ; HTASGKKVKI ; MQESLDKVKN ; LFDETQYVRK ; TTNFGHQESK ; 1600: PLKDREDYKE ; RLTLAYEKIE ; VTASKCEEMQ ; NFVSKQTEML ; PQQNDHMYRQ ; 1650: TENLTSNGSS ; PKVHGNIENK ; IEKNPRICCI ; CQSSYFVTED ; SALACYTGDS ; 1700: RKTCVGESSL ; SKGKKWLREQ ; SDKLGTRNTI ; EIQCVKEHTE ; DFAGNALYEH ; 1750: SLVIIRTEID ; TSHVSENQAS ; TLFSDPNVCH ; SYLSHSSFCH ; HDDMHNDSGY ; 1800: FLKDKIDSDV ; QPDMKNTEGN ; AIFPKISATK ; EIKLHPQTVN ; EECVQKLETN ; 1850: ASPYANKNIA ; IDSAMLDLRN ; CKVGSPVFIT ; THSQETVRMK ; EIFTDNCSKI ; 1900: VEQNRESKPD ; TCQTSCHKAL ; DNSEDFICPS ; SSGDVCINSP ; MAIFYPQSEQ ; 1950: ILQHNQSVSG ; LKKAATPPVS ; LETWDTCKSI ; RGSPQEVHPS ; RTYGFFSTAS ; 2000: GKAVQVSDAS ; LEKARQVFSE ; IDGDAKQLAS ; MVSLEGNEKS ; HHSVKRESSV ; 2050: VHNTHGVLSL ; RKTLPGNVSS ; FVFSGFSTAG ; GKLVTVSESA ; LHKVKGMLEE ; 2100: FDLIRTEHTL ; QHSPTPEDVS ; KIPPQPCLES ; RTPEYSVSSK ; LQKTYNDKSR ; 2150: SPSNYKESGS ; SGNTQSLEVS ; PQLSQMERKQ ; ETQSVLGTKV ; SQRKTNILEK ; 2200: KQNLPQNIKI ; ESNKMETFSD ; VSMKTNVGEY ; YSKEPENYFE ; TEAVEIAKAF ; 2250: MEDDELTDSE ; QTHAKCSLFA ; CPQNEALLNS ; RTRKRGGMAG ; VAVGQPPIKR ; 2300: SLLNEFDRII ; ESKGKSLTPS ; KSTPDGTIKD ; RRLFTHHMSL ; EPVTCGPFCS ; 2350: SKERQETQSP ; HVTSPAQGLQ ; SKEHPSRHSA ; VGKSSSNPTV ; SALRSERTRH ; 2400: SVSDKSTKVF ; VPPFKVKSRF ; HRDEHFDSKN ; VNLEGKNQKS ; ADGVSEDGND ; 2450: SDFPQFNKDL ; MSSLQNARDL ; QDIRIKNKER ; HHLCPQPGSL ; YLTKSSTLPR ; 2500: ISLQAAVGDS ; VPSACSPKQL ; YMYGVSKACI ; SVNSKNAEYF ; QFAIEDHFGK ; 2550: EALCAGKGFR ; LADGGWLIPS ; DDGKAGKEEF ; YRALCDTPGV ; DPKLISSVWV ; 2600: SNHYRWIVWK ; LAAMEFAFPK ; EFANRCLNPE ; RVLLQLKYRY ; DVEIDNSSRS ; 2650: ALKKILERDD ; TAAKTLVLCV ; SDIISLSTNV ; SETSGSKASS ; EDSNKVDTIE ; 2700: LTDGWYAVKA ; QLDPPLLALV ; KSGRLTVGQK ; IITQGAELVG ; SPDACAPLEA ; 2750: PDSLRLKISA ; NSTRPARWHS ; KLGFFHDPRP ; FPLPLSSLFS ; DGGNVGCVDV ; 2800: IVQRVYPLQW ; VEKTVSGSYI ; FRNEREEEKE ; ALRFAEAQQK ; KLEALFTKVH ; 2850: TELKEHEEDI ; AQRRVLSRAL ; TRQQVHALQD ; GAELYAAVQD ; ASDPEHLETC ; 2900: FSEEQLRALN ; NYRQMLSDKK ; QARIQSEFRK ; ALEAAEKEEG ; LSRDVSTVWK ; 2950: LRVTSYKKRE ; KSALLSIWRP ; SSDLPSLLTE ; GQRYRIYHLS ; VSKSKNKFEW ; 3000: PSIQLTATKR ; TQYQQLPVSS ; ETLLQLYQPR ; ELLPFSKLSD ; PAFQPPCSEV ; 3050: DVVGVVVSVV ; KPIGLAPLVY ; LSDECLHLLV ; VKFGIDLNED ; IKPRVLIAAS ; 3100: NLQWRPESTS ; RVPTLFAGNF ; SVFSASPKEA ; HFQERVTNMK ; HAIENIDTFY ; 3150: KEAEKKLIQV ; LKGDSPKWST ; PNKDPTREPY ; PASTCSASDL ; ASGGQLPRSS ; 3200: PTDQQSYRSP ; LSCCTPTGKS ; TPLAHSAWMA ; AKSCSGENEI ; EDPKTCRKKR ; 3250: ALDLLSRLPL ; PPPLSPVCTF ; VSPAAQKAFQ ; PPRSCGTKYP ; TPLKKEGPSS ; 3300: PWSRAPFQKA ; SGVSLLDCDS ; VADEELALLS ; TQALVPHSVG ; GSEQVFPSDS ; 3343: TRTEGPSAST ; EARPANRSKR ; ESLRDCRDDS ; DGKLAAETVP ; DYS
Sequence Length	3343
String	O35923
Sub Unit	Monomer and dimer. Interacts with RAD51 and DSS1. Interacts with both nonubiquitinated and monoubiquitinated FANCD2; this complex also includes XRCC3 and phosphorylated FANCG (By similarity). Interacts with WDR16. Interacts with USP11. Interacts with DMC1. Part of a trimeric complex containing BRCA1, BRCA2 and PALB2. Interacts with PALB2. Interacts with BRCA1 only in the presence of PALB2 which serves as the bridging protein. Interacts with ROCK2 and NPM1.

Uniprot	O35923
Gene Name	Brca2
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:360254
Unigene	Rn.103225

Reference	1. "Characterization of the rat and mouse homologues of the BRCA2 breast cancer susceptibility gene." McAllister K.A., Haugen-Strano A., Hagevik S., Brownlee H.A., Collins N.K., Futreal P.A., Bennett L.M., Wiseman R.W. Cancer Res.57:3121-3125(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Sprague-Dawley. tissue: Testis. 2. "BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure." Yang H., Jeffrey P.D., Miller J., Kinnucan E., Sun Y., Thoma N.H., Zheng N., Chen P.L., Lee W.H., Pavletich N.P. Science297:1837-1848(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF 2335-3151 IN COMPLEX WITH DSS1

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