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Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Beta-secretase 1

SKU : BHE13801203

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0718r
Alternative Names	Aspartyl protease 2 ; ASP2 ; Beta-site amyloid precursor protein cleaving enzyme 1 ; Beta-site APP cleaving enzyme 1 ; Memapsin-2 ; Membrane-associated aspartic protease 2 ; Bace
Categories	Elisa
Function	Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
Specificity	Natural and recombinant Rat Beta-secretase 1
Subcellular Location	Membrane Single-pass type I membrane protein Golgi apparatus trans-Golgi network Endoplasmic reticulum Endosome Cell surface Cytoplasmic vesicle membrane Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface.
Detection Range	0.78-50ng/mL
Entryname	BACE1_RAT
Method Type	Sandwich
Platform	PF00026
Protein Name	Beta-secretase 1
Sensitivity	0.39ng/mL
Sequence	50: MAPALRWLLL ; WVGSGMLPAQ ; GTHLGIRLPL ; RSGLAGPPLG ; LRLPRETDEE ; 100: PEEPGRRGSF ; VEMVDNLRGK ; SGQGYYVEMT ; VGSPPQTLNI ; LVDTGSSNFA ; 150: VGAAPHPFLH ; RYYQRQLSST ; YRDLRKSVYV ; PYTQGKWEGE ; LGTDLVSIPH ; 200: GPNVTVRANI ; AAITESDKFF ; INGSNWEGIL ; GLAYAEIARP ; DDSLEPFFDS ; 250: LVKQTHIPNI ; FSLQLCGAGF ; PLNQTEALAS ; VGGSMIIGGI ; DHSLYTGSLW ; 300: YTPIRREWYY ; EVIIVRVEIN ; GQDLKMDCKE ; YNYDKSIVDS ; GTTNLRLPKK ; 350: VFEAAVKSIK ; AASSTEKFPD ; GFWLGEQLVC ; WQAGTTPWNI ; FPVISLYLMG ; 400: EVTNQSFRIT ; ILPQQYLRPV ; EDVATSQDDC ; YKFAVSQSST ; GTVMGAVIME ; 450: GFYVVFDRAR ; KRIGFAVSAC ; HVHDEFRTAA ; VEGPFVTADM ; EDCGYNIPQT ; 500: DESTLMTIAY ; VMAAICALFM ; LPLCLMVCQW ; RCLRCLRHQH ; DDFADDISLL ; 501: K
Sequence Length	501
String	P56819
Sub Unit	Monomer. Interacts with GGA1, GGA2 and GGA3. Interacts with RTN3 and RTN4. Interacts with SNX6.

Uniprot	P56819
Gene Name	Bace1
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:29392
Unigene	Rn.207201

Reference	1. "Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE." Vassar R., Bennett B.D., Babu-Khan S., Kahn S., Mendiaz E.A., Denis P., Teplow D.B., Ross S., Amarante P., Loeloff R., Luo Y., Fisher S., Fuller J., Edenson S., Lile J., Jarosinski M.A., Biere A.L., Curran E., Burgess T., Louis J.-C., Collins F., Treanor J., Rogers G., Citron M.more... Science286:735-741(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]

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SKU	Supplier No.	Size	Your price	Quantity
BHE13801203	E0718r	96T	$796		Add to Cart

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