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ELISA Kit for Rat Bcl-2-like protein 1

SKU : BHE13801195

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15265r
Alternative Names	Apoptosis regulator Bcl-X ; Bclx ; Blc2l
Categories	Elisa
Function	Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane.
Specificity	Natural and recombinant Rat Bcl-2-like protein 1
Subcellular Location	Mitochondrion membrane Single-pass membrane protein Nucleus membrane Single-pass membrane protein Cytoplasmic side Mitochondrial membranes and perinuclear envelope.
Entryname	B2CL1_RAT
Platform	PF00452
Protein Name	Bcl-2-like protein 1
Sequence	50: MSQSNRELVV ; DFLSYKLSQK ; GYSWSQFSDV ; EENRTEAPEE ; TEPERETPSA ; 100: INGNPSWHLA ; DSPAVNGATG ; HSSSLDAREV ; IPMAAVKQAL ; REAGDEFELR ; 150: YRRAFSDLTS ; QLHITPGTAY ; QSFEQVVNEL ; FRDGVNWGRI ; VAFFSFGGAL ; 200: CVESVDKEMQ ; VLVSRIASWM ; ATYLNDHLEP ; WIQENGGWDT ; FVDLYGNNAA ; 233: AESRKGQERF ; NRWFLTGMTV ; AGVVLLGSLF ; SRK
Sequence Length	233
String	P53563
Sub Unit	Homodimer (By similarity). Isoform Bcl-X(L) forms heterodimers with BAX, BAK or BCL2. Heterodimerization with BAX does not seem to be required for anti-apoptotic activity. Interacts with BAD and BBC3. Interacts (isoform Bcl-X(L)) with SIVA1 (isoform 1); the interaction inhibits the anti-apoptotic activity. Interacts with BECN1 and PGAM5. Interacts (isoform Bcl-X(L)) with BAX (isoform Sigma). Interacts with BCL2L11 (By similarity). Interacts with DMN1L; the interaction stimulates the GTPase activity of DMN1L in synapses and increases the number of axonal mitochondria and the size and number of synaptic vesicle clusters. Isoform Bcl-X(L) interacts with IKZF3.

Uniprot	P53563
Gene Name	Bcl2l1
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:24888
Unigene	Rn.10323

Reference	1. Michaelidis T.M. Submitted (1994-12) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS BCL-X(L) AND BCL-X(S)) tissue: Brain. 2. "Cloning and expression of rat bcl-x in cultured neurons." Wesselingh S.L., David G.L., Choi S., Veliuona M., Hardwick J.M. Submitted (1995-06) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM BCL-X(L)) tissue: Brain. 3. "An additional form of rat Bcl-x, Bcl-xbeta, generated by an unspliced RNA, promotes apoptosis in promyeloid cells." Shiraiwa N., Inohara N., Okada S., Yuzaki M., Shoji S., Ohta S. J. Biol. Chem.271:13258-13265(1996) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS BCL-X(L) AND BCL-X(BETA));FUNCTION tissue: Thymus. 4. "Expression of members of the Bcl-2 gene family in the immature rat ovary: equine chorionic gonadotropin-mediated inhibition of granulosa cell apoptosis is associated with decreased Bax and constitutive Bcl-2 and Bcl-xlong messenger ribonucleic acid levels." Tilly J.L., Tilly K.I., Kenton M.L., Johnson A.L. Endocrinology136:232-241(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS BCL-X(L) AND BCL-X(S));FUNCTION strain: Sprague-Dawley. tissue: Ovary. 5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BCL-X(L)) tissue: Brain. 6. "Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons." Li H., Chen Y., Jones A.F., Sanger R.H., Collis L.P., Flannery R., McNay E.C., Yu T., Schwarzenbacher R., Bossy B., Bossy-Wetzel E., Bennett M.V., Pypaert M., Hickman J.A., Smith P.J., Hardwick J.M., Jonas E.A. Proc. Natl. Acad. Sci. U.S.A.105:2169-2174(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN SYNAPTIC VESICLE REGULATION;INTERACTION WITH DNM1L 7. "Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase." Alavian K.N., Li H., Collis L., Bonanni L., Zeng L., Sacchetti S., Lazrove E., Nabili P., Flaherty B., Graham M., Chen Y., Messerli S.M., Mariggio M.A., Rahner C., McNay E., Shore G.C., Smith P.J., Hardwick J.M., Jonas E.A.more... Nat. Cell Biol.13:1224-1233(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN SYNAPTIC VESICLE REGULATION;INTERACTION WITH ATP5A1 AND ATP5B;SUBCELLULAR LOCATION 8. "A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis." Li H., Alavian K.N., Lazrove E., Mehta N., Jones A., Zhang P., Licznerski P., Graham M., Uo T., Guo J., Rahner C., Duman R.S., Morrison R.S., Jonas E.A. Nat. Cell Biol.15:773-785(2013) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN SYNAPTIC VESICLE REGULATION;SUBCELLULAR LOCATION;INTERACTION WITH CLTA; DNM1L AND MFF 9. "Crystal structure of rat Bcl-xL. Implications for the function of the Bcl-2 protein family." Aritomi M., Kunishima N., Inohara N., Ishibashi Y., Ohta S., Morikawa K. J. Biol. Chem.272:27886-27892(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS)

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