JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Assay Kits / ELISA Kits

ELISA Kit for Rat Atypical chemokine receptor 2

SKU : BHE13800408

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

EIAAB SCIENCE INC, WUHAN

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	E14064r
Alternative Names	C-C chemokine receptor D6 ; CCR10-related receptor ; Chemokine-binding protein 2 ; Chemokine-binding protein D6 ; Ccbp2 ; Ccr10rr ; D6
Categories	Elisa
Function	Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs.
Specificity	Natural and recombinant Rat Atypical chemokine receptor 2
Subcellular Location	Early endosome Recycling endosome Cell membrane Multi-pass membrane protein Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via clathrin-coated pits. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.
Entryname	ACKR2_RAT
Platform	PF00001
Protein Name	Atypical chemokine receptor 2
Sequence	50: MPTIASPLPL ; ATTGPENGSS ; IYDYDYLDDV ; TVLVCSKDEV ; LSFGRVFLPV ; 100: VYSLIFVLGL ; AGNLLLLVVL ; LHSVPQRRRM ; IELYLLNLAV ; SNLLFVVTMP ; 150: FWAISVAWHW ; VFGSFLCKVV ; STLYSINFYC ; GIFFITCMSL ; DKYLEIVHAQ ; 200: PLHRPKTRFR ; NLLLIVMVWI ; TALAVSVPEM ; VFVKVHQTLD ; GVWHCYADFG ; 250: GHATIWKLYL ; RFQMNLLGFL ; FPLLAMIFFY ; SRIGCVLVRL ; RPPGQGRALR ; 300: MAAALVVVFF ; LLWFPYNLTL ; FLHSLLDLHV ; FGNCKISHRL ; DYMLQVTESL ; 350: AFSHCCFTPV ; LYAFSSHSFR ; QYLKAVLSVV ; LRRHQAPGTA ; HAPPCSHSES ; 382: SRVTAQEDVV ; SMNDLGERQA ; DISLNKGEIG ; NN
Sequence Length	382

Uniprot	O09027
Gene Name	Ackr2
Immunogen Species	Rattus norvegicus (Rat)
Unigene	Rn.10771

Reference	1. "Molecular cloning and expression of a novel rat CC-chemokine receptor (rCCR10rR) that binds MCP-1 and MIP-1beta with high affinity." Bonini J.A., Steiner D.F. DNA Cell Biol.16:1023-1030(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Sprague-Dawley.

Have you used this product?

Rate it now..!!

Login to Review

SKU	Supplier No.	Size	Your price	Quantity
BHE13800408	E14064r	96T	$796		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2024 Biohippo. All rights reserved.