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ELISA Kit for Rat Apoptosis-inducing factor 1, mitochondrial

SKU : BHE13800595

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1064r
Alternative Names	Programmed cell death protein 8 ; Aif ; Pdcd8
Categories	Elisa
Function	Probable oxidoreductase that has a dual role in controlling cellular life and death; during apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e., caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis,and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.
Specificity	Natural and recombinant Rat Apoptosis-inducing factor 1, mitochondrial
Subcellular Location	Mitochondrion intermembrane space Mitochondrion inner membrane Cytoplasm Cytoplasm perinuclear region Nucleus Proteolytic cleavage during or just after translocation into the mitochondrial intermembrane space (IMS) results in the formation of an inner-membrane-anchored mature form (AIFmit). During apoptosis, further proteolytic processing leads to a mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis. Colocalizes with EIF3G in the nucleus and perinuclear region.
Detection Range	0.156-10ng/mL
Entryname	AIFM1_RAT
Method Type	Sandwich
Platform	PF00070
Protein Name	Apoptosis-inducing factor 1, mitochondrial
Sensitivity	0.078ng/mL
Sequence	50: MFRCGGLAGA ; FKQKLVPLVR ; SVCVQRPKQR ; NRLPGNLFQQ ; WRVPLELQMA ; 100: RQMASSGPSG ; GKMDNSVLVL ; IVGLSTIGAG ; AYAYKTIKED ; QKRYNERIMG ; 150: LGLSPEEKQR ; RAIASAAEGG ; SVPPIRVPSH ; VPFLLIGGGT ; AAFAAARSIR ; 200: ARDPGARVLI ; VSEDPELPYM ; RPPLSKELWF ; SDDPNVTKTL ; QFRQWNGKER ; 250: SIYFQPPSFY ; VSAQDLPHIE ; NGGVAVLTGK ; KVVHLDVRGN ; MVKLNDGSQI ; 300: TFEKCLIATG ; GTPRSLSAID ; RAGAEVKSRT ; TLFRKIGDFR ; ALEKISREVK ; 350: SITVIGGGFL ; GSELACALGR ; KSQASGIEVI ; QLFPEKGNMG ; KILPEYLSNW ; 400: TMEKVKREGV ; KVMPNAIVQS ; VGVSGGKLLI ; KLKDGRKVET ; DHIVTAVGLE ; 450: PNVELAKTGG ; LEIDSDFGGF ; RVNAELQARS ; NIWVAGDAAC ; FYDIKLGRRR ; 500: VEHHDHAVVS ; GRLAGENMTG ; AAKPYWHQSM ; FWSDLGPDVG ; YEAIGLVDSS ; 550: LPTVGVFAKA ; TAQDNPKSAT ; EQSGTGIRSE ; SETESEASEI ; TIPPSDPAVP ; 600: QVPVEGEDYG ; KGVIFYLRDK ; VVVGIVLWNV ; FNRMPIARKI ; IKDGEQHEDL ; 612: NEVAKLFNIH ; ED
Sequence Length	612
String	Q9JM53
Sub Unit	Interacts with XIAP. Interacts (via N-terminus) with EIF3G (via C-terminus).

Uniprot	Q9JM53
Gene Name	Aifm1
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:83533
Unigene	Rn.203165

Reference	1. "Molecular cloning of rat apoptosis-inducing factor (AIF)." Ohsakaya S., Mihara K. Submitted (2000-04) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Liver. 2. "Cloning and characterization of rat apoptosis-inducing factor: implications for DNA fragmentation in cerebral ischemia." Cao G., Sheng L., Pei W., Chen J. Submitted (2001-05) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: Sprague-Dawley. tissue: Cerebellum. 3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Heart. 4. Lubec G., Kang S.U., Lubec S. Submitted (2007-09) to the UniProtKB [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 378-386;IDENTIFICATION BY MASS SPECTROMETRY strain: Sprague-Dawley. tissue: Brain.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13800595	E1064r	96T	$796		Add to Cart

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