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ELISA Kit for Rat Androgen receptor

SKU : BHE13800596

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1252r
Alternative Names	Dihydrotestosterone receptor ; Nuclear receptor subfamily 3 group C member 4 ; Nr3c4
Categories	Elisa
Function	Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3.
Specificity	Natural and recombinant Rat Androgen receptor
Subcellular Location	Nucleus Cytoplasm Predominantly cytoplasmic in unliganded form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unliganded form in the presence of GNB2L1.
Detection Range	78-5000pg/mL
Entryname	ANDR_RAT
Method Type	Sandwich
Platform	PF02166
Protein Name	Androgen receptor
Sensitivity	39.9pg/mL
Sequence	50: MEVQLGLGRV ; YPRPPSKTYR ; GAFQNLFQSV ; REAIQNPGPR ; HPEAASIAPP ; 100: GACLQQRQET ; SPRRRRRQQH ; PEDGSPQAHI ; RGTTGYLALE ; EEQQPSQQQS ; 150: ASEGHPESGC ; LPEPGAATAP ; GKGLPQQPPA ; PPDQDDSAAP ; STLSLLGPTF ; 200: PGLSSCSADI ; KDILSEAGTM ; QLLQQQQQQQ ; QQQQQQQQQQ ; QQQQQEVISE ; 250: GSSSVRAREA ; TGAPSSSKDS ; YLGGNSTISD ; SAKELCKAVS ; VSMGLGVEAL ; 300: EHLSPGEQLR ; GDCMYASLLG ; GPPAVRPTPC ; APLAECKGLS ; LDEGPGKGTE ; 350: ETAEYSSFKG ; GYAKGLEGES ; LGCSGSSEAG ; SSGTLEIPSS ; LSLYKSGAVD ; 400: EAAAYQNRDY ; YNFPLALSGP ; PHPPPPTHPH ; ARIKLENPSD ; YGSAWAAAAA ; 450: QCRYGDLASL ; HGGSVAGPST ; GSPPATASSS ; WHTLFTAEEG ; QLYGPGGGGG ; 500: SSSPSDAGPV ; APYGYTRPPQ ; GLASQEGDFS ; ASEVWYPGGV ; VNRVPYPSPS ; 550: CVKSEMGPWM ; ENYSGPYGDM ; RLDSTRDHVL ; PIDYYFPPQK ; TCLICGDEAS ; 600: GCHYGALTCG ; SCKVFFKRAA ; EGKQKYLCAS ; RNDCTIDKFR ; RKNCPSCRLR ; 650: KCYEAGMTLG ; ARKLKKLGNL ; KLQEEGENSS ; AGSPTEDPSQ ; KMTVSHIEGY ; 700: ECQPIFLNVL ; EAIEPGVVCA ; GHDNNQPDSF ; AALLSSLNEL ; GERQLVHVVK ; 750: WAKALPGFRN ; LHVDDQMAVI ; QYSWMGLMVF ; AMGWRSFTNV ; NSRMLYFAPD ; 800: LVFNEYRMHK ; SRMYSQCVRM ; RHLSQEFGWL ; QITPQEFLCM ; KALLLFSIIP ; 850: VDGLKNQKFF ; DELRMNYIKE ; LDRIIACKRK ; NPTSCSRRFY ; QLTKLLDSVQ ; 900: PIARELHQFT ; FDLLIKSHMV ; SVDFPEMMAE ; IISVQVPKIL ; SGKVKPIYFH ; 902: TQ
Sequence Length	902
String	P15207
Sub Unit	Binds DNA as a homodimer. Part of a ternary complex containing AR, EFCAB6/DJBP and PARK7. Interacts with HIPK3 and NR0B2 in the presence of androgen. The ligand binding domain interacts with KAT7/HBO1 in the presence of dihydrotestosterone. Interacts with EFCAB6/DJBP, PELP1, PQBP1, RANBP9, SPDEF, SRA1, TGFB1I1, ZNF318 and RREB1. The AR N-terminal poly-Gln region binds Ran resulting in enhancement of AR-mediated transactivation. Ran-binding decreases as the poly-Gln length increases. Interacts with ZMIZ1/ZIMP10 and ZMIZ2/ZMIP7 which both enhance its transactivation activity. Interacts with SLC30A9 and RAD54L2/ARIP4. Interacts with RBAK. Interacts via the ligand-binding domain with LXXLL and FXXLF motifs from NCOA1, NCOA2, NCOA3, NCOA4 and MAGEA11. Interacts with SLC30A9 and RAD54L2/ARIP4. Interacts with HIP1 (via coiled coil domain) (By similarity). Interacts with MACROD1 (By similarity). Interacts (via ligand-binding domain) with TRIM68 (By similarity). Interacts with TNK2 (By similarity). Interacts with USP26 (By similarity). Interacts with RNF6 (By similarity). Interacts (regulated by RNF6 probably through polyubiquitination) with RNF14; regulates AR transcriptional activity. Interacts with PRMT2 and TRIM24. Interacts with GNB2L1/RACK1 (By similarity). Interacts with RANBP10; this interaction enhances hormone-induced AR transcriptional activity (By similarity). Interacts with PRPF6 in a hormone-independent way; this interaction enhances hormone-induced AR transcriptional activity. Interacts with STK4/MST1.

Uniprot	P15207
Gene Name	Ar
Immunogen Species	Rattus norvegicus (Rat)
Kegg	rno:24208
Unigene	Rn.9813

Reference	1. "The rat androgen receptor: primary structure, autoregulation of its messenger ribonucleic acid, and immunocytochemical localization of the receptor protein." Tan J., Joseph D.R., Quarmby V.E., Lubahn D.B., Sar M., French F.S., Wilson E.M. Mol. Endocrinol.2:1276-1285(1988) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. "Structural analysis of complementary DNA and amino acid sequences of human and rat androgen receptors." Chang C., Kokontis J., Liao S. Proc. Natl. Acad. Sci. U.S.A.85:7211-7215(1988) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Prostate. 3. "A single base mutation in the androgen receptor gene causes androgen insensitivity in the testicular feminized rat." Yarbrough W.G., Quarmby V.E., Simental J.A., Joseph D.R., Sar M., Lubahn D.B., Olsen K.L., French F.S., Wilson E.M. J. Biol. Chem.265:8893-8900(1990) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT TFM GLN-735 4. "Activation of androgen receptor function by a novel nuclear protein kinase." Moilanen A.-M., Karvonen U., Poukka H., Jaenne O.A., Palvimo J.J. Mol. Biol. Cell9:2527-2543(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIPK3;SUBCELLULAR LOCATION tissue: Testis. 5. "A novel steroid receptor co-activator protein (SRAP) as an alternative form of steroid receptor RNA-activator gene: expression in prostate cancer cells and enhancement of androgen receptor activity." Kawashima H., Takano H., Sugita S., Takahara Y., Sugimura K., Nakatani T. Biochem. J.369:163-171(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SRA1 6. "Crystallographic structures of the ligand-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone." Sack J.S., Kish K.F., Wang C., Attar R.M., Kiefer S.E., An Y., Wu G.Y., Scheffler J.E., Salvati M.E., Krystek S.R. Jr., Weinmann R., Einspahr H.M. Proc. Natl. Acad. Sci. U.S.A.98:4904-4909(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 647-902 OF MUTANT ALA-860 IN COMPLEX WITH DIHYDROTESTOSTERONE 7. "Structural basis of androgen receptor binding to selective androgen response elements." Shaffer P.L., Jivan A., Dollins D.E., Claessens F., Gewirth D.T. Proc. Natl. Acad. Sci. U.S.A.101:4758-4763(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF 533-637 IN COMPLEX WITH DNA AND ZINC IONS;SUBUNIT 8. "Structure based approach to the design of bicyclic-1H-isoindole-1,3(2H)-dione based androgen receptor antagonists." Salvati M.E., Balog A., Shan W., Wei D.D., Pickering D., Attar R.M., Geng J., Rizzo C.A., Gottardis M.M., Weinmann R., Krystek S.R., Sack J., An Y., Kish K. Bioorg. Med. Chem. Lett.15:271-276(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 647-902 OF MUTANT ALA-860 IN COMPLEX WITH SYNTHETIC ANTAGONIST 9. "Discovery of potent, orally-active, and muscle-selective androgen receptor modulators based on an N-aryl-hydroxybicyclohydantoin scaffold." Sun C., Robl J.A., Wang T.C., Huang Y., Kuhns J.E., Lupisella J.A., Beehler B.C., Golla R., Sleph P.G., Seethala R., Fura A., Krystek S.R. Jr., An Y., Malley M.F., Sack J.S., Salvati M.E., Grover G.J., Ostrowski J., Hamann L.G.more... J. Med. Chem.49:7596-7599(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 647-902 IN COMPLEX WITH SYNTHETIC ANDROGEN ANTAGONIST;FUNCTION 10. "Pharmacological and X-ray structural characterization of a novel selective androgen receptor modulator: potent hyperanabolic stimulation of skeletal muscle with hypostimulation of prostate in rats." Ostrowski J., Kuhns J.E., Lupisella J.A., Manfredi M.C., Beehler B.C., Krystek S.R. Jr., Bi Y., Sun C., Seethala R., Golla R., Sleph P.G., Fura A., An Y., Kish K.F., Sack J.S., Mookhtiar K.A., Grover G.J., Hamann L.G. Endocrinology148:4-12(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 647-902 IN COMPLEX WITH THE SYNTHETIC AGONIST MBS-564929;FUNCTION

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