Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion.
Specificity
Natural and recombinant Rat Adenosine deaminase
Subcellular Location
Cell membrane Peripheral membrane protein Extracellular side Cell junction Cytoplasmic vesicle lumen Cytoplasm Colocalized with DPP4 at the cell junction in lymphocyte-epithelial cell adhesion.
"Restricted expression of adenosine deaminase in rat leptomeninges and its role in the regulation of sleep." Okada T., Mochizuki T., Huag Z., Sugita Y., Urade Y., Hayaishi O. Submitted (2001-04) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;SUBCELLULAR LOCATION;TISSUE SPECIFICITY