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Home / Assay Kits / ELISA Kits

ELISA Kit for Pig Villin-1

SKU : BHE13811585

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0193p
Alternative Names	VIL
Categories	Elisa
Function	Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol-4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair.
Specificity	Natural and recombinant Pig Villin-1
Subcellular Location	Cytoplasm cytoskeleton Cell projection lamellipodium Cell projection ruffle Cell projection microvillus Cell projection filopodium tip Cell projection filopodium Rapidly redistributed to ruffles and lamellipodia structures in response to autotaxin, lysophosphatidic acid (LPA) and epidermal growth factor (EGF) treatment. Redistributed to the leading edge of hepatocyte growth factor (HGF)-induced lamellipodia.
Detection Range	0.312-20ng/mL
Entryname	VILI_PIG
Method Type	Sandwich
Platform	PF00626
Protein Name	Villin-1
Sensitivity	0.167ng/mL
Sequence	50: MTKLNAQVKG ; SLNVTTPGVQ ; IWRIEAMQMV ; PVSSSTYGSF ; FDGDCYIVLA ; 100: IHKTGSNLSY ; DIHYWIGQDS ; SQDEQGAAAI ; YTTLMDDFLK ; GRAVQHREVQ ; 150: GNESEAFRGY ; FKQGIVIRKG ; GVASGMKKVE ; TNSYDIQRLL ; HVKGKRNVVA ; 200: GEVEMSWKSF ; NRGDVFLLDL ; GKLIIQWNGP ; ESNRMERLRG ; MTLAKEIRDQ ; 250: ERGGRTYVGV ; VDGEDEKASP ; QLMEIMNYVL ; GQRKELKAAV ; PDTVVEPALK ; 300: AALKLYHVSD ; SEGKVVVREV ; ATRPLTQDLL ; SHEDCYILDQ ; GGLKIYVWKG ; 350: KNANPQEKKE ; AMNQALNFIK ; AKQYPPSTQV ; EVQNDGAESA ; VFQQLFQKWT ; 400: VPNQTSGLGK ; THTVGSVAKV ; EQVKFDATSM ; HVQPQVAAQQ ; KMVDDGSGEV ; 450: EIWRIENLDL ; VPVESKWVGH ; FYGGDCYLLL ; YTYLIGEKQH ; YLLYIWQGSQ ; 500: ASQDEITASA ; YQAVILDQKY ; NNEPVQIRVP ; MGKEPPHLMS ; IFKGRMVVYQ ; 550: GGTSRANSTE ; PVPSTRLFQV ; RGTSVNNTKA ; FEVPARATSL ; NSNDIFVLKT ; 600: QSCCYLWCGK ; GCSGDEREMA ; KMVADTISRT ; EKQVVVEGQE ; PANFWVALGG ; 650: KAPYASSKRL ; QEETLVITPR ; LFECSNQTGR ; FLATEIPDFN ; QDDLEEDDVF ; 700: LLDVWDQVFF ; WIGKNANEDE ; KKAAAVTAQE ; YLKTHPSGRD ; PETPIIVVKQ ; 750: GYEPPTFTGW ; FLAWDPFKWS ; DSKSYEDLKA ; ELGNSGDWSQ ; ITAEIKNPKP ; 800: DVFNANTNLS ; SGPLPIFPLE ; QLVNKPAEEL ; PQGVDPSRRE ; EHLSIEDFTK ; 827: ALGMTPAAFS ; ALPRWKQQNL ; KKEKGLF
Sequence Length	827
String	Q29261
Sub Unit	Monomer. Homodimer; homodimerization is necessary for actin-bundling. Associates with F-actin; phosphorylation at tyrosines residues decreases the association with F-actin. Interacts (phosphorylated at C-terminus tyrosine phosphorylation sites) with PLCG1 (via the SH2 domains). Interacts (phosphorylated form) with PLCG1; the interaction is enhanced by hepatocyte growth factor (HGF).

Uniprot	Q29261
Gene Name	VIL1
Immunogen Species	Sus Scrofa (Pig)

Reference	1. "PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries." Uenishi H., Eguchi T., Suzuki K., Sawazaki T., Toki D., Shinkai H., Okumura N., Hamasima N., Awata T. Nucleic Acids Res.32:D484-D488(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Intestine. 2. "Evaluation and characterization of a porcine small intestine cDNA library: analysis of 839 clones." Winteroe A.K., Fredholm M., Davies W. Mamm. Genome7:509-517(1996) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 73-203 tissue: Small intestine.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13811585	E0193p	96T	$900		Add to Cart

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