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Home / Assay Kits / ELISA Kits

ELISA Kit for Pig Tissue-type plasminogen activator

SKU : BHE13811241

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0525p
Categories	Elisa
Function	Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events.
Specificity	Natural and recombinant Pig Tissue-type plasminogen activator
Subcellular Location	Secreted extracellular space
Entryname	TPA_PIG
Method Type	Sandwich
Platform	PF00008
Protein Name	Tissue-type plasminogen activator
Sequence	50: MYALKRELWC ; VLLLCGAICT ; SPSQETHRRL ; RRGVRSYRVT ; CRDEKTQMIY ; 100: QQHQSWLRPL ; LRGNRVEHCW ; CNDGQTQCHS ; VPVKSCSEPR ; CFNGGTCLQA ; 150: IYFSDFVCQC ; PVGFIGRQCE ; IDARATCYED ; QGITYRGTWS ; TTESGAECVN ; 200: WNTSGLASMP ; YNGRRPDAVK ; LGLGNHNYCR ; NPDKDSKPWC ; YIFKAEKYSP ; 250: DFCSTPACTK ; EKEECYTGKG ; LDYRGTRSLT ; MSGAFCLPWN ; SLVLMGKIYT ; 300: AWNSNAQTLG ; LGKHNYCRNP ; DGDTQPWCHV ; LKDHKLTWEY ; CDLPQCVTCG ; 350: LRQYKEPQFR ; IKGGLYADIT ; SHPWQAAIFV ; KNRRSPGERF ; LCGGILISSC ; 400: WVLSAAHCFQ ; ERFPPHHVRV ; VLGRTYRLVP ; GEEEQAFEVE ; KYIVHKEFDD ; 450: DTYDNDIALL ; QLKSDSLTCA ; QESDAVRTVC ; LPEANLQLPD ; WTECELSGYG ; 500: KHEASSPFYS ; ERLKEAHVRL ; YPSSRCTSKH ; LFNKTITNNM ; LCAGDTRSGG ; 550: DNANLHDACQ ; GDSGGPLVCM ; KGNHMTLVGV ; ISWGLGCGQK ; DVPGVYTKVT ; 562: NYLNWIRDNT ; RP
Sequence Length	562
String	Q8SQ23
Sub Unit	Heterodimer of chain A and chain B held by a disulfide bond. Binds to fibrin with high affinity. This interaction leads to an increase in the catalytic efficiency of the enzyme due to an increase in affinity for plasminogen. Similarly, binding to heparin increases the activation of plasminogen. Binds to annexin A2, cytokeratin-8, fibronectin and laminin. Binds to mannose receptor and the low-density lipoprotein receptor-related protein (LRP1); these proteins are involved in TPA clearance. Binds LRP1B; binding is followed by internalization and degradation.

Uniprot	Q8SQ23
Gene Name	PLAT
Immunogen Species	Sus Scrofa (Pig)
Kegg	ssc:397121
Unigene	Ssc.196

Reference	1. "T-plasminogen activator in tooth tissues." Ding Y., Xue J., Bartlett J.D. Submitted (2001-03) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Enamel organ.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13811241	E0525p	96T	$900		Add to Cart

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