ELISA Kit for Pig Thioredoxin

Mfr.No.	E0702p
Categories	Elisa
Function	Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.
Specificity	Natural and recombinant Pig Thioredoxin
Subcellular Location	Nucleus Cytoplasm Secreted Secreted by a leaderless secretory pathway. Predominantly in the cytoplasm in non irradiated cells. Radiation induces translocation of TRX from the cytoplasm to the nucleus.
Detection Range	3.12-200ng/mL
Entryname	THIO_PIG
Method Type	Sandwich
Platform	PF00085
Protein Name	Thioredoxin
Sensitivity	1.19ng/mL
Sequence	50: MVKQIESKYA ; FQEALNSAGE ; KLVVVDFSAT ; WCGPCKMIKP ; FFHSLSEKYS ; 100: NVVFLEVDVD ; DCQDVASECE ; VKCMPTFQFF ; KKGQKVGEFS ; GANKEKLEAT ; 105: INELI
Sequence Length	105
String	P82460
Sub Unit	Homodimer; disulfide-linked. Interacts with TXNIP through the redox-active site. Interacts with MAP3K5 and CASP3. Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA-binding activity in a redox-dependent manner.

Reference	1. "The cloning and expression of porcine thioredoxin in E. coli." Yu G.W., Xu J.Y., Xu L., Cheung P.Y., Lee K.S. Submitted (2001-05) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Liver. 2. Lee K.S., Tang W.K., Cheung P.Y., Siu Y.L., Wong N.S. Submitted (2000-05) to the UniProtKB [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-34 tissue: Erythrocyte.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810771	E0702p	96T	$900		Add to Cart