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Home / Assay Kits / ELISA Kits

ELISA Kit for Pig NF-kappa-B inhibitor alpha

SKU : BHE13805610

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1848p
Alternative Names	ECI-6 ; I-kappa-B-alpha ; IkB-alpha ; IKBA
Categories	Elisa
Function	Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription.
Specificity	Natural and recombinant Pig NF-kappa-B inhibitor alpha
Subcellular Location	Cytoplasm Nucleus Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export.
Entryname	IKBA_PIG
Platform	PF12796
Protein Name	NF-kappa-B inhibitor alpha
Sequence	50: MFQPAEPGQE ; WAMEGPRDAL ; KKERLLDDRH ; DSGLDSMKDE ; EYEQMVKELR ; 100: EIRLEPQEAP ; RGAEPWKQQL ; TEDGDSFLHL ; AIIHEEKALT ; MEVVRQVKGD ; 150: LAFLNFQNNL ; QQTPLHLAVI ; TNQPEIAEAL ; LEAGCDPELR ; DFRGNTPLHL ; 200: ACEQGCLASV ; GVLTQPRGTQ ; HLHSILQATN ; YNGHTCLHLA ; SIHGYLGIVE ; 250: LLVSLGADVN ; AQEPCNGRTA ; LHLAVDLQNP ; DLVSLLLKCG ; ADVNRVTYQG ; 300: YSPYQLTWGR ; PSTRIQQQLG ; QLTLENLQML ; PESEDEESYD ; TESEFTEDEL ; 314: PYDDCVLGGQ ; RLTL
Sequence Length	314
String	Q08353
Sub Unit	Interacts with RELA; the interaction requires the nuclear import signal. Interacts with NKIRAS1 and NKIRAS2. Part of a 70-90 kDa complex at least consisting of CHUK, IKBKB, NFKBIA, RELA, IKBKAP and MAP3K14. Interacts with HBV protein X. Interacts with RWDD3; the interaction enhances sumoylation. Interacts (when phosphorylated at the 2 serine residues in the destruction motif D-S-G-X(2,3,4)-S) with BTRC. Associates with the SCF(BTRC) complex, composed of SKP1, CUL1 and BTRC; the association is mediated via interaction with BTRC. Part of a SCF(BTRC)-like complex lacking CUL1, which is associated with RELA; RELA interacts directly with NFKBIA. Interacts with PRMT2.

Uniprot	Q08353
Gene Name	NFKBIA
Immunogen Species	Sus Scrofa (Pig)
Kegg	ssc:406188
Unigene	Ssc.4759

Reference	1. "Cytokine-inducible expression in endothelial cells of an IkappaB alpha-like gene is regulated by NF-kappaB." De Martin R., Vanhove B., Cheng Q., Hofer E., Csizmadia V., Winkler H., Bach F.H. EMBO J.12:2773-2779(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] tissue: Aorta. 2. "Intron-exon structure of the porcine IkappaB alpha-encoding gene." De Martin R., Holzmueller H., Hofer E., Bach F.H. Gene152:253-255(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] 3. "Species-specific variation in RELA underlies differences in NF-kappaB activity: a potential role in African swine fever pathogenesis." Palgrave C.J., Gilmour L., Lowden C.S., Lillico S.G., Mellencamp M.A., Whitelaw C.B. J. Virol.85:6008-6014(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-314 tissue: Blood.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805610	E1848p	96T	$900		Add to Cart

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