Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Specificity
Natural and recombinant Pig Catechol O-methyltransferase
Subcellular Location
Cytoplasm Cell membrane Single-pass type II membrane protein Extracellular side