ELISA Kit for Pig Caspase-3

Mfr.No.	E0626p
Categories	Elisa
Function	Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp- ; -Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9.
Specificity	Natural and recombinant Pig Caspase-3
Subcellular Location	Cytoplasm
Detection Range	0.312-20ng/mL
Entryname	CASP3_PIG
Method Type	Sandwich
Platform	PF00656
Protein Name	Caspase-3
Sensitivity	0.083ng/mL
Sequence	50: MENNKTSVDS ; KSIKTLETKI ; LHGSKSMDSG ; ISLDVSYKMD ; YPEMGLCIII ; 100: NNKNFDKNTG ; MACRSGTDVD ; AANLRETFTN ; LKYEVRNKND ; LTREEILELM ; 150: HSVSKEDHSK ; RSSFICVLLS ; HGEEGKIFGT ; NGPVDLKKLT ; SFFRGDCCRT ; 200: LTGKPKLFII ; QACRGTELDC ; GIETDSGTED ; DMACQKIPVE ; ADFLYAYSTA ; 250: PGYYSWRNSK ; DGSWFIQSLC ; AALKQYVHKL ; ELMHILTRVN ; RKVAVEFESF ; 277: STDSTFHAKK ; QIPCIVSMLT ; KELYFYH
Sequence Length	277
String	Q95ND5
Sub Unit	Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit (By similarity). Subunit p17 interacts with asfivirus A224L protein.

Reference	1. "Porcine caspase-3: its cloning and activity during apoptosis of PK15 cells induced by porcine Fas ligand." Muneta Y., Shimojima Y., Mori Y. J. Interferon Cytokine Res.21:409-415(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. "African swine fever virus IAP homologue inhibits caspase activation and promotes cell survival in mammalian cells." Nogal M.L., Gonzalez de Buitrago G., Rodriguez C., Cubelos B., Carrascosa A.L., Salas M.L., Revilla Y. J. Virol.75:2535-2543(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ASFIVIRUS A224L

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SKU	Supplier No.	Size	Your price	Quantity
BHE13801643	E0626p	96T	$900		Add to Cart