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Home / Assay Kits / ELISA Kits

ELISA Kit for Pig Amyloid beta A4 protein

SKU : BHE13800610

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0946p
Alternative Names	ABPP ; APP ; Alzheimer disease amyloid A4 protein homolog ; Amyloid precursor protein ; Beta-amyloid precursor protein
Categories	Elisa
Function	N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
Specificity	Natural and recombinant Pig Amyloid beta A4 protein
Subcellular Location	Membrane Single-pass type I membrane protein Membrane clathrin-coated pit Cell surface protein that rapidly becomes internalized via clathrin-coated pits. During maturation, the immature APP (N-glycosylated in the endoplasmic reticulum) moves to the Golgi complex where complete maturation occurs (O-glycosylated and sulfated). After alpha-secretase cleavage, soluble APP is released into the extracellular space and the C-terminal is internalized to endosomes and lysosomes. Some APP accumulates in secretory transport vesicles leaving the late Golgi compartment and returns to the cell surface. Gamma-CTF(59) peptide is located to both the cytoplasm and nuclei of neurons.
Entryname	A4_PIG
Platform	PF10515
Protein Name	Amyloid beta A4 protein
Sequence	50: MLPGLALVLL ; AAWTARALEV ; PTDGNAGLLA ; EPQVAMFCGK ; LNMHMNVQNG ; 100: KWESDPSGTK ; TCIGTKEGIL ; QYCQEVYPEL ; QITNVVEANQ ; PVTIQNWCKR ; 150: SRKQCKTHTH ; IVIPYRCLVG ; EFVSDALLVP ; DKCKFLHQER ; MDVCETHLHW ; 200: HTVAKETCSE ; KSTNLHDYGM ; LLPCGIDKFR ; GVEFVCCPLA ; EESDNIDSAD ; 250: AEEDDSDVWW ; GGADTDYADG ; SEDKVVEVAE ; EEEVADVEEE ; EAEDDEDDED ; 300: GDEVEEEAEE ; PYEEATERTT ; SIATTTTTTT ; ESVEEVVREV ; CSEQAETGPC ; 350: RAMISRWYFD ; VTEGKCAPFF ; YGGCGGNRNN ; FDTEEYCMAV ; CGSVMSQSLL ; 400: KTTQEHLPQD ; PVKLPTTAAS ; TPDAVDKYLE ; TPGDENEHAH ; FQKAKERLEA ; 450: KHRERMSQVM ; REWEEAERQA ; KNLPKADKKA ; VIQHFQEKVE ; SLEQEAANER ; 500: QQLVETHMAR ; VEAMLNDRRR ; LALENYITAL ; QAVPPRPRHV ; FNMLKKYVRA ; 550: EQKDRQHTLK ; HFEHVRMVDP ; KKAAQIRSQV ; MTHLRVIYER ; MNQSLSLLYN ; 600: VPAVAEEIQD ; EVDELLQKEQ ; NYSDDVLANM ; ISEPRISYGN ; DALMPSLTET ; 650: KTTVELLPVN ; GEFSLDDLQP ; WHPFGVDSVP ; ANTENEVEPV ; DARPAADRGL ; 700: TTRPGSGLTN ; IKTEEISEVK ; MDAEFRHDSG ; YEVHHQKLVF ; FAEDVGSNKG ; 750: AIIGLMVGGV ; VIATVIVITL ; VMLKKKQYTS ; IHHGVVEVDA ; AVTPEERHLS ; 770: KMQQNGYENP ; TYKFFEQMQN ;
Sequence Length	770
String	P79307
Sub Unit	Binds, via its C-terminus, to the PID domain of several cytoplasmic proteins, including APBB family members, the APBA family, MAPK8IP1, and SHC1, NUMB and DAB1 (By similarity). Binding to Dab1 inhibits its serine phosphorylation (By similarity). Also interacts with GPCR-like protein BPP, FPRL1, APPBP1, IB1, KNS2 (via its TPR domains) (By similarity), APPBP2 (via BaSS) and DDB1. In vitro, it binds MAPT via the MT-binding domains (By similarity). Associates with microtubules in the presence of ATP and in a kinesin-dependent manner (By similarity). Interacts with CPEB1, ANKS1B, TNFRSF21 and AGER (By similarity). Interacts with ITM2B. Interacts with ITM2C. Interacts with IDE. Can form homodimers; this is promoted by heparin binding.

Uniprot	P79307
Gene Name	APP
Immunogen Species	Sus Scrofa (Pig)
Kegg	ssc:397663
Unigene	Ssc.14258

Reference	1. "Amyloid precursor protein 770." Kimura A., Takahashi T. Submitted (1999-09) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. "Evaluation and characterization of a porcine small intestine cDNA library." Winteroe A.K., Fredholm M. Submitted (1997-01) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-136 tissue: Small intestine. 3. "Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain reaction analysis." Johnstone E.M., Chaney M.O., Norris F.H., Pascual R., Little S.P. Brain Res. Mol. Brain Res.10:299-305(1991) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 667-723 tissue: Brain.

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BHE13800610	E0946p	96T	$900		Add to Cart

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