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ELISA Kit for Mouse Wilms tumor protein 1-interacting protein

SKU : BHE13811813

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2052m
Categories	Elisa
Function	May monitor slit diaphragm protein assembly, a specialized adherens junction characteristic of podocytes. In case of podocyte injury, it shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype.
Specificity	Natural and recombinant Mouse Wilms tumor protein 1-interacting protein
Subcellular Location	Cell junction adherens junction Nucleus Translocates from cell-cell junctions to the nucleus in puromycin aminonucleoside-treated podocytes.
Detection Range	0.625-40 ng/mL
Entryname	WTIP_MOUSE
Method Type	Sandwich
Platform	PF00412
Protein Name	Wilms tumor protein 1-interacting protein
Sensitivity	0.312 ng/mL
Sequence	50: MQRSRTAADD ; AALLLAGLGL ; RESEPTAGSP ; GRVRRGPRAV ; DEAAPASGRR ; 100: GKGGCGGPEA ; APDVPSRPER ; GPRASLAGSD ; GGSARSSGIS ; LGYDQRHGPG ; 150: PGPPSGGSAR ; SSVSSLGSRG ; SAGACADLLP ; PGVGPAPARS ; PEPAQFPFPL ; 200: PSLPLPPGRE ; GGPSAAERRL ; EALTRELERA ; LEARTARDYF ; GICIKCGLGI ; 250: YGARQACQAM ; GSLYHTDCFI ; CDSCGRRLRG ; KAFYNVGEKV ; YCQEDFLYSG ; 300: FQQTADKCSV ; CGHLIMEMIL ; QALGKSYHPG ; CFRCSVCNEC ; LDGVPFTVDV ; 350: DNNIYCVRDY ; HTVFAPKCAS ; CARPILPAQG ; CETTIRVVSM ; DRDYHVECYH ; 398: CEDCGLQLSG ; EEGRRCYPLE ; GHLLCRRCHL ; RRLGQGPLPS ; PAVHVTEL
Sequence Length	398
String	Q7TQJ8
Sub Unit	Interacts with CD2AP and WT1.

Uniprot	Q7TQJ8
Gene Name	Wtip
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:101543
Unigene	Mm.422738

Reference	1. "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.more... PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] strain: C57BL/6J. 2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Limb. 3. "A WT1 co-regulator controls podocyte phenotype by shuttling between adhesion structures and nucleus." Srichai M.B., Konieczkowski M., Padiyar A., Konieczkowski D.J., Mukherjee A., Hayden P.S., Kamat S., El-Meanawy M.A., Khan S., Mundel P., Lee S.B., Bruggeman L.A., Schelling J.R., Sedor J.R. J. Biol. Chem.279:14398-14408(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;INTERACTION WITH WT1 AND CD2AP 4. "WT1-interacting protein and ZO-1 translocate into podocyte nuclei after puromycin aminonucleoside treatment." Rico M., Mukherjee A., Konieczkowski M., Bruggeman L.A., Miller R.T., Khan S., Schelling J.R., Sedor J.R. Am. J. Physiol.289:F431-F441(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION 5. "The Ajuba LIM domain protein is a corepressor for SNAG domain mediated repression and participates in nucleocytoplasmic Shuttling." Ayyanathan K., Peng H., Hou Z., Fredericks W.J., Goyal R.K., Langer E.M., Longmore G.D., Rauscher F.J. III Cancer Res.67:9097-9106(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION 6. "Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus." Langer E.M., Feng Y., Zhaoyuan H., Rauscher F.J. III, Kroll K.L., Longmore G.D. Dev. Cell14:424-436(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SNAI1; SNAI2/SLUG AND SCRT1 7. "The LIM domain protein Wtip interacts with the receptor tyrosine kinase Ror2 and inhibits canonical Wnt signalling." van Wijk N.V., Witte F., Feike A.C., Schambony A., Birchmeier W., Mundlos S., Stricker S. Biochem. Biophys. Res. Commun.390:211-216(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ROR2;HOMODIMERIZATION;SUBCELLULAR LOCATION;DEVELOPMENTAL STAGE 8. "Podocyte injury induces nuclear translocation of WTIP via microtubule-dependent transport." Kim J.H., Konieczkowski M., Mukherjee A., Schechtman S., Khan S., Schelling J.R., Ross M.D., Bruggeman L.A., Sedor J.R. J. Biol. Chem.285:9995-10004(2010) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH MAPK8IP3 AND DYNEIN INTERMEDIATE CHAIN;TISSUE SPECIFICITY 9. "WT1-interacting protein (Wtip) regulates podocyte phenotype by cell-cell and cell-matrix contact reorganization." Kim J.H., Mukherjee A., Madhavan S.M., Konieczkowski M., Sedor J.R. Am. J. Physiol.302:F103-F115(2012) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION

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