B7 homolog 4 ; B7-H4 ; Immune costimulatory protein B7-H4 ; Protein B7S1 ; T cell costimulatory molecule B7x ; B7h4
Categories
Elisa
Function
Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.