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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Ubiquitin thioesterase otulin

SKU : BHE13808003

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15311m
Alternative Names	Deubiquitinating enzyme otulin ; OTU domain-containing deubiquitinase with linear linkage specificity ; Ubiquitin thioesterase Gumby ; Fam105b ; Gum
Categories	Elisa
Function	Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. Associates with the LUBAC complex via direct interaction with RNF31 and counteracts its action by cleaving linear polyubiquitin chains to substrates. Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex. Acts as a negative regulator of NF-kappa-B by counteracting activity of the LUBAC complex. Plays a key role in innate immune response: required to restrict linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling.
Specificity	Natural and recombinant Mouse Ubiquitin thioesterase otulin
Subcellular Location	Cytoplasm
Entryname	OTUL_MOUSE
Platform	PF10275
Protein Name	Ubiquitin thioesterase otulin
Sequence	50: MSRGTMPQPG ; AWPGASCAET ; PAREAGAAAR ; DGGKVTAGAQ ; PRAATRCPAE ; 100: HEEDMYRAAD ; EIEKEKELLI ; HERGISEPRL ; SVAPEMDIMD ; YCKKEWRGNT ; 150: QKATCMKKGY ; EEVSQKFTSI ; RRVRGDNYCA ; LRATLFQAMS ; QLAELPPWLQ ; 200: DLELILLPEK ; LINKYTWIKQ ; WKLGLKFDGK ; SEDLVEKIKE ; SLALLRKKWV ; 250: SLAAMKTAEA ; RQTACDELFT ; NEEEEYSLYE ; AVKFLMLNRA ; IELYDDKEKG ; 300: KEVPFFSVLL ; FARDTSNDPE ; QLLRNHLNQV ; GHTGGLEQVE ; MFLLAYAVRH ; 350: SIRVYRLSKY ; NTEEFITVYP ; TDPPKDWPMV ; TLIAEDDRHY ; NIPVRVCEET ; 352: SV
Sequence Length	352
Sub Unit	Interacts with RNF31; the interaction is direct. Interacts with DVL2.

Uniprot	Q3UCV8
Gene Name	Otulin
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:432940
Unigene	Mm.309164

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808003	E15311m	96T	$776		Add to Cart

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