ELISA Kit for Mouse Ubiquitin-conjugating enzyme E2 A

Mfr.No.	E0991m
Alternative Names	E2 ubiquitin-conjugating enzyme A ; RAD6 homolog A ; HR6A ; Ubiquitin carrier protein A ; Ubiquitin-protein ligase A ; Rad6a
Categories	Elisa
Function	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA.
Specificity	Natural and recombinant Mouse Ubiquitin-conjugating enzyme E2 A
Detection Range	78-5000pg/mL
Entryname	UBE2A_MOUSE
Method Type	Sandwich
Platform	PF00179
Protein Name	Ubiquitin-conjugating enzyme E2 A
Sensitivity	39.1pg/mL
Sequence	50: MSTPARRRLM ; RDFKRLQEDP ; PAGVSGAPSE ; NNIMVWNAVI ; FGPEGTPFED ; 100: GTFKLTIEFT ; EEYPNKPPTV ; RFVSKMFHPN ; VYADGSICLD ; ILQNRWSPTY ; 150: DVSSILTSIQ ; SLLDEPNPNS ; PANSQAAQLY ; QENKREYEKR ; VSAIVEQSWR ; 152: DC
Sequence Length	152
String	Q9Z255
Sub Unit	Interacts with RAD18 and WAC.

Reference	1. "Isolation of mHR6A, a gene highly homologous to the male fertility gene mHR6B." Roest H.P., van Klaveren J., Koken M.H.M., Vermey M., van Cappellen W.A., Baarends W.M., Hoogerbrugge J.W., Bootsma D., Hoeijmakers J.H.J., Grootegoed J.A., de Wit J. Submitted (1998-08) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: BCBA. tissue: Brain. 2. Kwon Y.T., Varshavsky A. Submitted (2001-05) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: C57BL/6. tissue: Skeletal muscle. 3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]

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