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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Tyrosine-protein kinase SYK

SKU : BHE13806534

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1520m
Alternative Names	Spleen tyrosine kinase ; ptk72 ; Sykb
Categories	Elisa
Function	Positive effector of BCR-stimulated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-342 and Tyr-346. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion. Likewise, mediates responses to ITGB2 signaling and plays an important role in the regulation of down-stream signaling cascades. Phosphorylates USP25 and regulates its intracellular levels.
Specificity	Natural and recombinant Mouse Tyrosine-protein kinase SYK
Detection Range	0.312-20ng/mL
Entryname	KSYK_MOUSE
Method Type	Sandwich
Platform	PF07714
Protein Name	Tyrosine-protein kinase SYK
Sensitivity	0.156ng/mL
Sequence	50: MAGSAVDSAN ; HLTYFFGNIT ; REEAEDYLVQ ; GGMTDGLYLL ; RQSRNYLGGF ; 100: ALSVAHNRKA ; HHYTIERELN ; GTYAISGGRA ; HASPADLCHY ; HSQEPDGLIC ; 150: LLKKPFNRPP ; GVQPKTGPFE ; DLKENLIREY ; VKQTWNLQGQ ; ALEQAIISQK ; 200: PQLEKLIATT ; AHEKMPWFHG ; NISRDESEQT ; VLIGSKTNGK ; FLIRARDNSG ; 250: SYALCLLHEG ; KVLHYRIDRD ; KTGKLSIPEG ; KKFDTLWQLV ; EHYSYKPDGL ; 300: LRVLTVPCQK ; IGAQMGHPGS ; PNAHPVTWSP ; GGIISRIKSY ; SFPKPGHKKP ; 350: APPQGSRPES ; TVSFNPYEPT ; GGPWGPDRGL ; QREALPMDTE ; VYESPYADPE ; 400: EIRPKEVYLD ; RSLLTLEDNE ; LGSGNFGTVK ; KGYYQMKKVV ; KTVAVKILKN ; 450: EANDPALKDE ; LLAEANVMQQ ; LDNPYIVRMI ; GICEAESWML ; VMEMAELGPL ; 500: NKYLQQNRHI ; KDKNIIELVH ; QVSMGMKYLE ; ESNFVHRDLA ; ARNVLLVTQH ; 550: YAKISDFGLS ; KALRADENYY ; KAQTHGKWPV ; KWYAPECINY ; YKFSSKSDVW ; 600: SFGVLMWEAF ; SYGQKPYRGM ; KGSEVTAMLE ; KGERMGCPAG ; CPREMYDLMN ; 629: LCWTYDVENR ; PGFTAVELRL ; RNYYYDVVN
Sequence Length	629
String	P48025
Sub Unit	Interacts with YWHAG/1433-gamma, which attenuates BCR-induced membrane translocation and activation (By similarity). Interacts (phosphorylated form) with SLA; the interaction may link it to CBL, leading to its destruction. Interacts with FCRL3. Interacts (via the second SH2 domain) with USP25 (via C-terminus) (By similarity). Interacts with RHOH, GAB2 and with NFAM1 (phosphorylated form). Interacts (via its SH2 domains) with CD79A (via its phosphorylated ITAM domain); the interaction stimulates SYK autophosphorylation and activation. Interacts with ITGB2 and FGR.

Uniprot	P48025
Gene Name	Syk
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:20963
Unigene	Mm.375031

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806534	E1520m	96T	$776		Add to Cart

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