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ELISA Kit for Mouse Transcription factor AP-1

SKU : BHE13805761

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1292m
Alternative Names	AH119 ; Activator protein 1 ; AP1 ; Proto-oncogene c-Jun ; V-jun avian sarcoma virus 17 oncogene homolog ; Jun A
Categories	Elisa
Function	Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
Specificity	Natural and recombinant Mouse Transcription factor AP-1
Subcellular Location	Nucleus
Detection Range	7.8-500ng/mL
Entryname	JUN_MOUSE
Method Type	Sandwich
Platform	PF00170
Protein Name	Transcription factor AP-1
Sensitivity	4.04ng/mL
Sequence	50: MTAKMETTFY ; DDALNASFLQ ; SESGAYGYSN ; PKILKQSMTL ; NLADPVGSLK ; 100: PHLRAKNSDL ; LTSPDVGLLK ; LASPELERLI ; IQSSNGHITT ; TPTPTQFLCP ; 150: KNVTDEQEGF ; AEGFVRALAE ; LHSQNTLPSV ; TSAAQPVSGA ; GMVAPAVASV ; 200: AGAGGGGGYS ; ASLHSEPPVY ; ANLSNFNPGA ; LSSGGGAPSY ; GAAGLAFPSQ ; 250: PQQQQQPPQP ; PHHLPQQIPV ; QHPRLQALKE ; EPQTVPEMPG ; ETPPLSPIDM ; 300: ESQERIKAER ; KRMRNRIAAS ; KCRKRKLERI ; ARLEEKVKTL ; KAQNSELAST ; 334: ANMLREQVAQ ; LKQKVMNHVN ; SGCQLMLTQQ ; LQTF
Sequence Length	334
String	P05627
Sub Unit	Heterodimer with either FOS or BATF3 or ATF7 (By similarity). The ATF7/JUN heterodimer is essential for ATF7 transactivation activity. Interacts with SP1, SPIB and TCF20. Interacts with COPS5; the interaction leads indirectly to its phosphorylation. Component of the SMAD3/SMAD4/JUN/FOS/complex which forms at the AP1 promoter site. The SMAD3/SMAD4 heterodimer acts syngernistically with the JUN/FOS heterodimer to activate transcription in response to TGF-beta (By similarity). Interacts (via its basic DNA binding and leucine zipper domains) with SMAD3 (via an N-terminal domain); the interaction is required for TGF-beta-mediated transactivation of the SMAD3/SMAD4/JUN/FOS/complex (By similarity). Interacts with DSIPI; the interaction inhibits the binding of active AP1 to its target DNA. Interacts with HIVEP3 and MYBBP1A. Interacts with RNF187. Binds to HIPK3.

Uniprot	P05627
Gene Name	Jun
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:16476
Unigene	Mm.275071

Reference	1. "Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts." Ryseck R.-P., Hirai S., Yaniv M., Bravo R. Nature334:535-537(1988) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. "Induction of proto-oncogene JUN/AP-1 by serum and TPA." Lamph W.W., Wamsley P., Sassone-Corsi P., Verma I.M. Nature334:629-631(1988) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 3. "Induction of protooncogene c-jun by serum growth factors." Ryder K., Nathans D. Proc. Natl. Acad. Sci. U.S.A.85:8464-8467(1988) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Mammary tumor. 5. "Molecular cloning reveals that the p160 Myb-binding protein is a novel, predominantly nucleolar protein which may play a role in transactivation by Myb." Tavner F.J., Simpson R., Tashiro S., Favier D., Jenkins N.A., Gilbert D.J., Copeland N.G., Macmillan E.M., Lutwyche J., Keough R.A., Ishii S., Gonda T.J. Mol. Cell. Biol.18:989-1002(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MYBBP1A 6. "Inhibition of AP-1 by the glucocorticoid-inducible protein GILZ." Mittelstadt P.R., Ashwell J.D. J. Biol. Chem.276:29603-29610(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DSIPI 7. "Schnurri-3 (KRC) interacts with c-Jun to regulate the IL-2 gene in T cells." Oukka M., Wein M.N., Glimcher L.H. J. Exp. Med.199:15-24(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIVEP3;FUNCTION 8. "Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylation." Lan H.-C., Li H.-J., Lin G., Lai P.-Y., Chung B.-C. Mol. Cell. Biol.27:2027-2036(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION BY HIPK3 9. "The phagosomal proteome in interferon-gamma-activated macrophages." Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P. Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] 10. "Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation." Davies C.C., Chakraborty A., Cipriani F., Haigh K., Haigh J.J., Behrens A. Nat. Cell Biol.12:963-972(2010) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RNF187 11. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways." Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y. Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-56;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] tissue: Embryonic fibroblast.

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