ELISA Kit for Mouse TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Mfr.No.

E2881m

Alternative Names

Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 ; TAK1-binding protein 3 ; TAB-3 ; TGF-beta-activated kinase 1-binding protein 3 ; Kiaa4135 ; Map3k7ip3

Categories

Elisa

Function

Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL-1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor.

Specificity

Natural and recombinant Mouse TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Detection Range

78-5000pg/mL

Entryname

TAB3_MOUSE

Linearity

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	92-105%	90-101%	95-105%	92-109%
EDTA plasma(n=5)	89-95%	93105%	89-94%	90-106%
heparin plasma(n=5)	93-104%	94-110%	101-111%	91-110%

Method Type

Sandwich

Platform

PF02845

Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤3.9%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤7.7%

Protein Name

TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Recovery

Recovery was determined by spiking various levels of ACE into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	99	91-103
Plasma	98	93-106

Sensitivity

39.4pg/mL

Sequence

50:

MAQNSPQLDI ; QVLHDLRQRF ; PEIPEGVVSQ ; CMLQNNNNLE ; ACCRALSQES ;

100:

SKYLYMEYHS ; PEDNRMNRNR ; LLHINLGIHS ; PSSYHPGDGA ; HLNGGRTLVH ;

150:

SSSDGHIDPQ ; HTAGKQLICL ; VQEPHSAPAV ; VAATPNYNPF ; FMNEQNRSAA ;

200:

TPPSQPPQQP ; SSMQTGMNPS ; AMQGPSPPPP ; PPSYMHIPRY ; STNPITVTVS ;

250:

QNLPSGQTVP ; RALQILPQIP ; SNLYGSPGSI ; FIRQTSQSSS ; GRQTPQNAPW ;

300:

QSSPQGPVPH ; YSQRPLPVYP ; HQQNYQPSQY ; SPKQQQIPQS ; VYHSPPPSQC ;

350:

PSPFSSPQHQ ; VQPPQLGHPS ; SHVFMPPSPS ; TTPPHLYQQG ; PPSYQKPGSH ;

400:

SVAYLPYTAS ; SLPKGSMKKI ; EITVEPSQRP ; GTAITRSPSP ; ISNQPSPRNQ ;

450:

HSLYTATTPP ; SSSPSRGISS ; QPKPPFSVNP ; VYITYTQPTG ; PSCAPSPSPR ;

500:

VIPNPTTVFK ; ITVGRATTEN ; LLNLVDQEER ; SAAPEPIQPI ; SVIPGSGGEK ;

550:

GNHKYQRSSS ; SGSDDYAYTQ ; ALLLHQRARM ; ERLAKQLKLE ; KEELERLKAE ;

600:

VNSMEHDLMQ ; RRLRRVSCTT ; AIPTPEEMTR ; LRSTNRQLQI ; NVDCTLKEVD ;

650:

LLQSRGNFDP ; KAINNFYDHI ; EPGPVVPPKP ; SKKDSSDSCA ; IERKARRISV ;

700:

TSKAPVDIHD ; AQAAAADEHL ; SICKQSARTQ ; PRDEDYEGAP ; WNCDSCTFLN ;

716:

HPALNRCEQC ; EMPRYT

Sequence Length

716

String

Q571K4

Sub Unit

Interacts with TAB1, TAB2, MAP3K7, TRAF2 and TRAF6. The minimal TAB3-containing complex (TAB1-MAP3K7-TAB3) appears not to contain TAB2. However, it seems sensible to consider that TAB2 may also join this complex and may act in a cooperative manner with TAB3. Interacts with WDR34 (via the WD domains). Interacts with RBCK1.

Uniprot	Q571K4
Gene Name	Tab3
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:66724
Unigene	Mm.119646

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810145	E2881m	96T	$776		Add to Cart

ELISA Kit for Mouse TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

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