Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
Specificity
Natural and recombinant Mouse Src-like-adapter 2
Subcellular Location
Cytoplasm Cell membrane Cytoplasmic vesicle Late endosome Localized to the plasma membrane and intracellular vesicles, including late endosomal vesicles.