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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Sorting nexin-1

SKU : BHE13810725

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15090m
Categories	Elisa
Function	May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).
Specificity	Natural and recombinant Mouse Sorting nexin-1
Subcellular Location	Endosome membrane Peripheral membrane protein Cytoplasmic side Golgi apparatus trans-Golgi network membrane Peripheral membrane protein Cytoplasmic side Early endosome membrane Peripheral membrane protein Cytoplasmic side Enriched on tubular elements of the early endosome membrane. Binds preferentially to highly curved membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).
Entryname	SNX1_MOUSE
Method Type	Sandwich
Platform	PF00787
Protein Name	Sorting nexin-1
Sequence	50: MASGGGGCSA ; SERLPPPFPG ; MDPESEGAAG ; ASEPEAGDSD ; TEGEDIFTGA ; 100: AAATKPQSPK ; KTTSLFPIKN ; GSKENGIHED ; QDQEPQDLFA ; DATVELSLDS ; 150: TQNNQKTMPG ; KTLTSHSPQE ; ATNSPKPQPS ; YEELEEEEQE ; DQFDLTVGIT ; 200: DPEKIGDGMN ; AYVAYKVTTQ ; TSLPMFRSRQ ; FAVKRRFSDF ; LGLYEKLSEK ; 250: HSQNGFIVPP ; PPEKSLIGMT ; KVKVGKEDSS ; SAEFLEKRRA ; ALERYLQRIV ; 300: NHPTMLQDPD ; VREFLEKEEL ; PRAVGTQALS ; GAGLLKMFNK ; ATDAVSKMTI ; 350: KMNESDIWFE ; EKLQEVECEE ; QRLRKLHAVV ; ETLVNHRKEL ; ALNTALFAKS ; 400: LAMLGSSEDN ; TALSRALSQL ; AEVEEKIEQL ; HQEQANNDSF ; LLAELLSDYI ; 450: RLLAIVRAAF ; DQRMKTWQRW ; QDAQATLQKK ; RESEARLLWA ; NKPDKLQQAK ; 500: DEITEWESRV ; TQYERDFERI ; STVVRKEVTR ; FEKEKSKDFK ; NHVMKYLETL ; 522: LHSQQQLAKY ; WEAFLPEAKA ; IS
Sequence Length	522
String	Q9WV80
Sub Unit	Self-assembles into a complex of approximately 300 kDa. Interacts with HGS. Component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2. Interacts with SNX6.

Uniprot	Q9WV80
Gene Name	Snx1
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:56440
Unigene	Mm.271891

Reference	1. "Complete sequence of mouse sorting nexin 1 (Snx1) cDNA." Takahara K., Omatsu Y., Maeda Y., Shimoyama S., Inaba K. Submitted (1999-05) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Thymus. 2. "Association of mouse sorting nexin 1 with early endosomes." Nakamura N., Sun-Wada G.H., Yamamoto A., Wada Y., Futai M. J. Biochem.130:765-771(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBUNIT strain: C57BL/6. 3. "Genetic analysis of sorting nexins 1 and 2 reveals a redundant and essential function in mice." Schwarz D.G., Griffin C.T., Schneider E.A., Yee D., Magnuson T. Mol. Biol. Cell13:3588-3600(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE 4. "Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-188;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] tissue: Liver.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810725	E15090m	96T	$776		Add to Cart

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