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ELISA Kit for Mouse Sodium-dependent serotonin transporter

SKU : BHE13809984

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2290m
Alternative Names	5HT transporter ; 5HTT ; Solute carrier family 6 member 4 ; Htt ; Sert
Categories	Elisa
Function	Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
Specificity	Natural and recombinant Mouse Sodium-dependent serotonin transporter
Subcellular Location	Cell membrane Multi-pass membrane protein Endomembrane system Multi-pass membrane protein Endosome membrane Translocates from intracellular locations to the plasma membrane. Density of transporter molecules on the plasma membrane is itself regulated by serotonin.
Detection Range	15.6-1000pg/mL
Entryname	SC6A4_MOUSE
Method Type	Sandwich
Platform	PF03491
Protein Name	Sodium-dependent serotonin transporter
Sensitivity	8.02pg/mL
Sequence	50: METTPLNSQK ; VLSECKDKED ; CQENGVLQKG ; VPTPADKAGP ; GQISNGYSAV ; 100: PSTSAGDEAP ; HSTPAATTTL ; VAEIHQGERE ; TWGKKMDFLL ; SVIGYAVDLG ; 150: NIWRFPYICY ; QNGGGAFLLP ; YTIMAIFGGI ; PLFYMELALG ; QYHRNGCISI ; 200: WKKICPIFKG ; IGYAICIIAF ; YIASYYNTII ; AWALYYLISS ; FTDQLPWTSC ; 250: KNSWNTGNCT ; NYFAQDNITW ; TLHSTSPAEE ; FYLRHVLQIH ; QSKGLQDLGT ; 300: ISWQLALCIM ; LIFTIIYFSI ; WKGVKTSGKV ; VWVTATFPYI ; VLSVLLVRGA ; 350: TLPGAWRGVV ; FYLKPNWQKL ; LETGVWVDAA ; AQIFFSLGPG ; FGVLLAFASY ; 400: NKFNNNCYQD ; ALVTSVVNCM ; TSFVSGFVIF ; TVLGYMAEMR ; NEDVSEVAKD ; 450: AGPSLLFITY ; AEAIANMPAS ; TFFAIIFFLM ; LITLGLDSTF ; AGLEGVITAV ; 500: LDEFPHIWAK ; RREWFVLIVV ; ITCILGSLLT ; LTSGGAYVVT ; LLEEYATGPA ; 550: VLTVALIEAV ; VVSWFYGITQ ; FCSDVKEMLG ; FSPGWFWRIC ; WVAISPLFLL ; 600: FIICSFLMSP ; PQLRLFQYNY ; PHWSIILGYC ; IGTSSVICIP ; IYIIYRLIST ; 630: PGTLKERIIK ; SITPETPTEI ; PCGDIRMNAV ;
Sequence Length	630
String	Q60857
Sub Unit	Monomer or homooligomer (By similarity). Interacts (via C-terminus) with VIM. Interacts (via C-terminus) with SCAMP2; the interaction is direct and retains transporter molecules intracellularly. Interacts with GTP-bound RAB4 (GTP-bound form); the interaction retains transporter molecules intracellularly. Interacts (via sialylated form) with MYH9. Interacts with filamentous actin and STX1A (By similarity). Interacts with SEC23A, SEC24C and INADL. Interacts with NOS1; the interaction may diminish the cell surface localization of SERT in the brain and, correspondingly, reduce serotonin reuptake. Interacts with TGFB1I1.

Uniprot	Q60857
Gene Name	Slc6a4
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:15567
Unigene	Mm.300318

Reference	1. "Cloning and expression of the mouse serotonin transporter." Chang A.S., Chang S.M., Starnes D.M., Schroeter S., Bauman A.L., Blakely R.D. Brain Res. Mol. Brain Res.43:185-192(1996) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. "Gene structure and 5'-flanking regulatory region of the murine serotonin transporter." Bengel D., Heils A., Petri S., Seemann M., Glatz K., Andrews A., Murphy D.L., Lesch K.P. Brain Res. Mol. Brain Res.44:286-292(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] strain: 129. 3. "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.more... PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] strain: C57BL/6J. 4. Saito N., Sakai N., Kobayashi S., Fujimoto M., Morikawa O., Ikegaki N. Submitted (1995-05) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-114 strain: BALB/c. 5. "Murine serotonin transporter: sequence and localization to chromosome 11." Gregor P., Patel A., Shimada S., Lin C.L., Rochelle J.M., Kitayama S., Seldin M.F., Uhl G.R. Mamm. Genome4:283-284(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 69-630 6. "Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ('Ecstasy') in serotonin transporter-deficient mice." Bengel D., Murphy D.L., Andrews A.M., Wichems C.H., Feltner D., Heils A., Mossner R., Westphal H., Lesch K.P. Mol. Pharmacol.53:649-655(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE 7. "Serotonin-, protein kinase C-, and Hic-5-associated redistribution of the platelet serotonin transporter." Carneiro A.M.D., Blakely R.D. J. Biol. Chem.281:24769-24780(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TGFB1I1 8. "Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity." Chanrion B., Mannoury la Cour C., Bertaso F., Lerner-Natoli M., Freissmuth M., Millan M.J., Bockaert J., Marin P. Proc. Natl. Acad. Sci. U.S.A.104:8119-8124(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NOS1; SEC23A; SEC24C AND INADL 9. "Zic2 regulates the expression of Sert to modulate eye-specific refinement at the visual targets." Garcia-Frigola C., Herrera E. EMBO J.29:3170-3183(2010) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE 10. "Role of activating transcription factor-4 in 24-hour rhythm of serotonin transporter expression in the mouse midbrain." Ushijima K., Koyanagi S., Sato Y., Ogata T., Matsunaga N., Fujimura A., Ohdo S. Mol. Pharmacol.82:264-270(2012) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION

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