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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Smoothened homolog

SKU : BHE13810417

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15161m
Alternative Names	Smoh
Categories	Elisa
Function	G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.
Specificity	Natural and recombinant Mouse Smoothened homolog
Subcellular Location	Membrane Multi-pass membrane protein
Detection Range	0.156-10ng/mL
Entryname	SMO_MOUSE
Method Type	Sandwich
Platform	PF01534
Protein Name	Smoothened homolog
Sensitivity	0.084ng/mL
Sequence	50: MAAGRPVRGP ; ELAPRRLLQL ; LLLVLLGGPG ; RGAALSGNVT ; GPGPHSASGS ; 100: SRRDVPVTSP ; PPPLLSHCGR ; AAHCEPLRYN ; VCLGSALPYG ; ATTTLLAGDS ; 150: DSQEEAHGKL ; VLWSGLRNAP ; RCWAVIQPLL ; CAVYMPKCEN ; DRVELPSRTL ; 200: CQATRGPCAI ; VERERGWPDF ; LRCTPDHFPE ; GCPNEVQNIK ; FNSSGQCEAP ; 250: LVRTDNPKSW ; YEDVEGCGIQ ; CQNPLFTEAE ; HQDMHSYIAA ; FGAVTGLCTL ; 300: FTLATFVADW ; RNSNRYPAVI ; LFYVNACFFV ; GSIGWLAQFM ; DGARREIVCR ; 350: ADGTMRFGEP ; TSSETLSCVI ; IFVIVYYALM ; AGVVWFVVLT ; YAWHTSFKAL ; 400: GTTYQPLSGK ; TSYFHLLTWS ; LPFVLTVAIL ; AVAQVDGDSV ; SGICFVGYKN ; 450: YRYRAGFVLA ; PIGLVLIVGG ; YFLIRGVMTL ; FSIKSNHPGL ; LSEKAASKIN ; 500: ETMLRLGIFG ; FLAFGFVLIT ; FSCHFYDFFN ; QAEWERSFRD ; YVLCQANVTI ; 550: GLPTKKPIPD ; CEIKNRPSLL ; VEKINLFAMF ; GTGIAMSTWV ; WTKATLLIWR ; 600: RTWCRLTGHS ; DDEPKRIKKS ; KMIAKAFSKR ; RELLQNPGQE ; LSFSMHTVSH ; 650: DGPVAGLAFD ; LNEPSADVSS ; AWAQHVTKMV ; ARRGAILPQD ; VSVTPVATPV ; 700: PPEEQANMWL ; VEAEISPELE ; KRLGRKKKRR ; KRKKEVCPLR ; PAPELHHSAP ; 750: VPATSAVPRL ; PQLPRQKCLV ; AANAWGTGES ; CRQGAWTLVS ; NPFCPEPSPH ; 793: QDPFLPGASA ; PRVWAQGRLQ ; GLGSIHSRTN ; LMEAEILDAD ; SDF
Sequence Length	793
String	P56726
Sub Unit	Interacts with ARRB2. Interacts with KIF7.

Uniprot	P56726
Gene Name	Smo
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:319757
Unigene	Mm.29279

Reference	1. "Cloning of a mouse Smoothened cDNA and expression patterns of hedgehog signalling molecules during chondrogenesis and cartilage differentiation in clonal mouse EC cells, ATDC5." Akiyama H., Shigeno C., Hiraki Y., Shukunami C., Kohno H., Akagi M., Konishi J., Nakamura T. Biochem. Biophys. Res. Commun.235:142-147(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.more... PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] strain: C57BL/6J. 3. "Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2." Chen W., Ren X.R., Nelson C.D., Barak L.S., Chen J.K., Beachy P.A., de Sauvage F., Lefkowitz R.J. Science306:2257-2260(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARRB2 4. "A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened." Seo S., Zhang Q., Bugge K., Breslow D.K., Searby C.C., Nachury M.V., Sheffield V.C. PLoS Genet.7:E1002358-E1002358(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH THE BBSOME COMPLEX;INTERACTION WITH BBS5 AND BBS7

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810417	E15161m	96T	$776		Add to Cart

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