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ELISA Kit for Mouse Smoothelin-like protein 1

SKU : BHE13810894

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2278m
Alternative Names	Calponin homology-associated smooth muscle protein ; CHASM
Categories	Elisa
Function	Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-301 reduces this inhibitory activity.
Specificity	Natural and recombinant Mouse Smoothelin-like protein 1
Subcellular Location	Cytoplasm myofibril sarcomere I band Cytoplasm myofibril sarcomere M line Nucleus Colocalizes with MYH2. In its unphosphorylated state, localizes to the cytoplasm. Phosphorylation at Ser-301 promotes translocation to the nucleus.
Detection Range	31.2-2000pg/mL
Entryname	SMTL1_MOUSE
Method Type	Sandwich
Platform	PF00307
Protein Name	Smoothelin-like protein 1
Sensitivity	15.6pg/mL
Sequence	50: MEQTEGNSSE ; DGTTVSPTAG ; NLETPGSQGI ; AEEVAEGTVG ; TSDKEGPSDW ; 100: AEHLCKAASK ; SGESGGSPGE ; ASILDELKTD ; LQGEARGKDE ; AQGDLAEEKV ; 150: GKEDTTAASQ ; EDTGKKEETK ; PEPNEVREKE ; EAMLASEKQK ; VDEKETNLES ; 200: KEKSDVNDKA ; KPEPKEDAGA ; EVTVNEAETE ; SQEEADVKDQ ; AKPELPEVDG ; 250: KETGSDTKEL ; VEPESPTEEQ ; EQGKENESEE ; RAAVIPSSPE ; EWPESPTDEG ; 300: PSLSPDGLAP ; ESTGETSPSA ; SESSPSEVPG ; SPTEPQPSEK ; KKDRAPERRV ; 350: SAPSRPRGPR ; AQNRKAIMDK ; FGGAASGPTA ; LFRNTKAAGA ; AIGGVKNMLL ; 400: EWCRAMTRNY ; EHVDIQNFSS ; SWSSGMAFCA ; LIHKFFPEAF ; DYAELDPAKR ; 450: RHNFTLAFST ; AEKLADCAQL ; LEVDDMVRLA ; VPDSKCVYTY ; IQELYRSLVQ ; 459: KGLVKTKKK
Sequence Length	459
String	Q99LM3
Sub Unit	Interacts with PPP1R12A.

Uniprot	Q99LM3
Gene Name	Smtnl1
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:68678
Unigene	Mm.33452

Reference	1. "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.more... PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] strain: C57BL/6J. 2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: FVB/N. tissue: Mammary tumor. 3. "Modulation of smooth muscle contractility by CHASM, a novel member of the smoothelin family of proteins." Borman M.A., MacDonald J.A., Haystead T.A. FEBS Lett.573:207-213(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-301;MUTAGENESIS OF SER-301 4. "Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle." Wooldridge A.A., Fortner C.N., Lontay B., Akimoto T., Neppl R.L., Facemire C., Datto M.B., Kwon A., McCook E., Li P., Wang S., Thresher R.J., Miller S.E., Perriard J.C., Gavin T.P., Hickner R.C., Coffman T.M., Somlyo A.V., Yan Z., Haystead T.A.more... J. Biol. Chem.283:11850-11859(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;PHOSPHORYLATION AT SER-301;DISRUPTION PHENOTYPE;INDUCTION;MUTAGENESIS OF SER-301 5. "Smoothelin-like 1 protein regulates myosin phosphatase-targeting subunit 1 expression during sexual development and pregnancy." Lontay B., Bodoor K., Weitzel D.H., Loiselle D., Fortner C., Lengyel S., Zheng D., Devente J., Hickner R., Haystead T.A. J. Biol. Chem.285:29357-29366(2010) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PPP1R12A;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;PHOSPHORYLATION AT SER-301;DEVELOPMENTAL STAGE;DISRUPTION PHENOTYPE;MUTAGENESIS OF SER-301 6. "Solution structure of the calponin homology (CH) domain from the smoothelin-like 1 protein: a unique apocalmodulin-binding mode and the possible role of the C-terminal type-2 CH-domain in smooth muscle relaxation." Ishida H., Borman M.A., Ostrander J., Vogel H.J., MacDonald J.A. J. Biol. Chem.283:20569-20578(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 346-459;CALMODULIN BINDING

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